Butenafine Hydrochloride

Trade Names:Lotrimin Ultra- Cream 1%

Trade Names:Mentax- Cream 1%

Pharmacology

Appears to inhibit biosynthesis of the ergosterol component of fungal cell membranes.

Indications and Usage

Interdigital tinea pedis (athlete's foot); tinea corporis (ringworm); tinea cruris (jock itch); tinea (pityriasis) versicolor caused by susceptible organisms.

Contraindications

Standard considerations.

Dosage and Administration

Topical Apply to affected and surrounding area(s) twice daily for 7 days or every day for 4 wk.

Topical Apply every day for 2 wk.

General Advice

• For topical use only. Not for ophthalmic, oral, or intravaginal use.
• Avoid contact with eyes, eyelids, lips, and mucus membranes.
• Apply enough cream to cover affected area(s) and the immediately surrounding skin and gently massage cream into skin.

Storage/Stability

Store at controlled room temperature or in refrigerator (41° to 86°F). Keep tube tightly capped.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Dermatologic

Worsening of condition, burning, stinging, itching (1%).

Precautions

Pregnancy

Category B .

Lactation

Undetermined.

Children

Safety and efficacy in children younger than 12 yr of age not established.

Patient Information

• Advise patient that medication is applied topically to skin lesions every day or twice daily.
• Teach patient proper technique for applying cream: wash hands; ensure that area to be treated is dry; apply a thin film of cream to cover affected area(s) and immediately surrounding skin areas; gently massage into skin; wash hands after applying medication.
• Advise patient that improvement may take several days to weeks to occur and to continue applying the medication for entire treatment time recommended by health care provider.
• Instruct patient to notify health care provider if improvement is not noted after the end of the treatment period, or sooner if condition worsens.
• Caution patient not to cover treated areas with bandages or dressings unless advised by health care provider.
• Advise patient that if an application is missed to not try to make it up but to return to normal application schedule as soon as possible.
• Warn patient to avoid contact with the eyes, eyelids, lips, and mucous membranes.
• Advise patient that if cream comes in contact with the eyes to wash eyes with large amounts of cool water and to contact health care provider if eye irritation persists.
• Advise patient that local stinging, burning, itching, and redness are most common adverse reactions and to notify health care provider if they become bothersome.
• Advise patient to stop using the medication and contact health care provider if severe skin reactions occur (eg, blistering, swelling, oozing).

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