Generic Name: belladonna and opium (rectal) (BEL a DON a and OH pee um)Brand names: B & O Supprettes 15-A, B & O Supprettes 16-A, B & O Supprettes 15-A, B & O Supprettes 16-A
Belladonna is a natural substance made from a toxic plant. The medicinal form of belladonna has many effects in the body, such as decreasing muscle activity.
Opium is also a natural substance made from the seeds of a plant. The medicinal form of opium is a narcotic pain reliever.
The combination of belladonna and opium is used to treat moderate to severe pain caused by muscle spasms in the tubes that connect the kidneys to the bladder.
Belladonna and opium may also be used for other purposes not listed in this medication guide.
Do not use belladonna and opium if you are also using furazolidone (Furoxone), linezolid (Zyvox), moclobemide, pramlintide (Symlin), procarbazine (Matulane), naltrexone (ReVia), or potassium supplement tablets or capsules.You should not use belladonna and opium if you have glaucoma, urination problems, a blockage in your stomach or intestines, a head injury, seizures, diarrhea caused by infection, severe liver or kidney disease, severe bleeding, myasthenia gravis, asthma, or if you are intoxicated or debilitated.
Before using this medication, tell your doctor if you have liver or kidney disease, heart disease, high or low blood pressure, a stomach or intestinal disorder, breathing problems, mental illness, spinal curvature, gallbladder disease, Addison's disease, underactive thyroid, drug or alcohol addiction, or if you are allergic to any narcotic medications.Opium may be habit-forming and should be used only by the person it was prescribed for. Belladonna and opium rectal suppositories should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.What should I discuss with my health care provider before using belladonna and opium rectal?Do not use belladonna and opium if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you use belladonna and opium before the MAO inhibitor has cleared from your body.
Do not use belladonna and opium if you are also using furazolidone (Furoxone), linezolid (Zyvox), moclobemide, pramlintide (Symlin), procarbazine (Matulane), naltrexone (ReVia), or potassium supplement tablets or capsules.You should not use this medication if you are allergic to belladonna or opium, or if you have:
urination problems or an enlarged prostate;
severe kidney disease;
a blockage in your stomach or intestines;
a history of head injury or brain tumor;
epilepsy or other seizure disorder;
an infection causing diarrhea;
severe liver disease;
a muscle disorder such as myasthenia gravis;
asthma or severe breathing disorder;
if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications; or
if you are bed-ridden or otherwise debilitated.
If you have certain conditions, you may need a dose adjustment or special tests to safely use belladonna and opium. Before using, tell your doctor if you have:
liver or kidney disease;
heart disease, high or low blood pressure;
a stomach or intestinal disorder;
chronic obstructive pulmonary disease (COPD) or other breathing problems;
depression or mental illness;
curvature of the spine;
Addison's disease or other adrenal gland disorders;
drug or alcohol addiction; or
an allergy to atropine or any narcotic pain medicine such as hydrocodone (Lortab, Vicodin), morphine (Kadian, MS Contin, Oramorph, and others), oxycodone (OxyContin), and others.
Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.Do not take belladonna and opium rectal by mouth. It is for use only in your rectum.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.Wash your hands before and after inserting the rectal suppository.
Try to empty your bowel and bladder just before using the belladonna and opium suppository. Use this medicine at a time when you can lie down afterward and hold the medicine in for a few minutes.
Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands. Moisten the suppository with water to make it easier to insert.
Lie on your back with your knees up toward your chest. Gently insert the suppository into your rectum about 1 inch.
For best results, stay lying down after inserting the suppository and hold it in your rectum for a few minutes. The suppository will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom for at least an hour after using the suppository.
Drink plenty of water to prevent constipation while using belladonna and opium.
Belladonna and opium rectal is most often used 1 or 2 times per day. Do not use the suppositories more than 4 times per day. Follow your doctor's instructions. Call your doctor if your symptoms do not improve, or if they get worse while using this medication.Do not stop using the medication suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when you stop using belladonna and opium rectal. Store the rectal suppositories at room temperature away from moisture, heat, and light. Do not refrigerate or freeze this medication.
Ask your pharmacist how to properly dispose of any unused suppositories that are no longer needed.Keep track of how many suppositories have been used from each new bottle of this medicine. Opium is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.
Since this medication is often used only when needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra suppositories to make up the missed dose.
Overdose symptoms may include feeling restless or excited, confusion or unusual behavior, muscle weakness, weak or shallow breathing, fainting, or coma.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.Avoid drinking alcohol. It can increase some of the side effects of belladonna and opium.
Belladonna and opium can cause constipation. Avoid using any type of laxative without asking your doctor.
painful or difficult urination;
urinating less than usual or not at all;
fast heart rate;
weak, shallow breathing;
extreme weakness, feeling like you might pass out;
headache, confusion; or
severe constipation and stomach pain.
Less serious side effects may include:
nausea, vomiting, constipation;
dry mouth, dry eyes;
decreased sense of taste; or
impotence, loss of interest in sex, or trouble having an orgasm.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Many drugs can interact with belladonna and opium. Below is just a partial list. Tell your doctor if you are using:
a blood thinner such as warfarin (Coumadin);
rifampin (Rifadin, Rifater, Rifamate);
cold or allergy medicines;
an antidepressant such as amitriptyline (Elavil, Etrafon), nortriptyline (Pamelor), trazodone (Desyrel), and others;
medicine to treat a mental illness, such as clozapine (Clozaril, FazaClo), chlorpromazine (Thorazine), and others;
diazepam (Valium) or similar medicines such as alprazolam (Xanax), clorazepate (Tranxene), lorazepam (Ativan), midazolam (Versed), temazepam (Restoril), triazolam (Halcion), and others;
a beta-blocker such as atenolol (Tenormin), bisoprolol (Zebeta, Ziac), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others; or
other narcotic pain medicine such as fentanyl (Actiq, Duragesic), hydrocodone (Lortab, Vicodin), hydromorphone (Dilaudid, Palladone), morphine (Kadian, MS Contin, Oramorph, and others), oxycodone (OxyContin), oxymorphone (Numorphan, Opana), and others.
This list is not complete and there may be other drugs that can interact with belladonna and opium. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.