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Drugs reference index «Zegerid»



Generic name: Omeprazole, Sodium bicarbonateBrand names: Zegerid

Why is Zegerid prescribed?

Zegerid is used to treat intestinal ulcers (duodenal ulcers), stomach ulcers (gastric ulcers), gastroesophageal reflux disease (GERD), and erosive esophagitis. It contains omeprazole, a proton pump inhibitor, and sodium bicarbonate, an antacid, which alters stomach acid and thus improves the absorption of omeprazole.

Most important fact about Zegerid

Both the capsule and oral suspension forms of Zegerid should always be taken on an empty stomach, with water. Do not substitute any other food or liquid in the place of water.

How should you take Zegerid?

Zegerid should be taken with water on an empty stomach. Take it at least 1 hour before a meal. Do not use any other liquid than water.

Swallow the capsules whole; do not open the capsule and sprinkle on food. Zegerid oral suspension should be emptied into a small cup with 1-2 tablespoons of water. Stir well and drink. Refill the cup with water and drink the remainder.

  • Storage instructions...Store both the capsules and oral suspension at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zegerid.

  • Side effects may include:Aching, back pain, constipation, cough, diarrhea, dizziness, headache, nausea, rash, upper respiratory infection, vomiting

Why should Zegerid not be prescribed?

Do not take Zegerid if you are allergic to any of its ingredients.

Special warnings about Zegerid

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zegerid.

Also, talk to your doctor about your complete medical history, especially if you are on a sodium-restricted diet. Zegerid capsules contain 300 milligrams of sodium per dose in the form of sodium bicarbonate. Zegerid oral suspension contains 460 milligrams of sodium per dose in the form of sodium bicarbonate. This should be taken into consideration if you need to be on a sodium-restricted diet. In addition, sodium bicarbonate should not be used by people with metabolic alkalosis or hypocalcemia (low blood levels of calcium).

Possible food and drug interactions when taking Zegerid

If Zegerid is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zegerid with the following:

AtazanavirDiazepamOther proton pump inhibitorsPhenytoinTacrolimusWarfarin

Special information if you are pregnant or breastfeeding

The effects of Zegerid during pregnancy and breastfeeding are unknown. Talk with your doctor before taking Zegerid if you are pregnant, plan to become pregnant, or are breastfeeding.

Recommended dosage for Zegerid


Benign Gastric UlcerThe recommended dosage is 40 milligrams (mg) once daily for 4-8 weeks.

Erosive EsophagitisThe recommended dosage is 20 mg once daily for 4-8 weeks. To maintain healing of erosive esophagitis, the daily dose is 20 mg for as long as the doctor prescribes Zegerid.

Short-Term Treatment of Active Duodenal UlcerThe recommended dosage is 20 mg once daily for 4 weeks.

Symptomatic GERDThe recommended dosage is 20 mg once daily for up to 4 weeks.

Upper Gastrointestinal BleedingThe recommended initial dosage is 40 mg followed by another 40 mg 6-8 hours later, and 40 mg daily thereafter for 14 days.


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

  • Symptoms of Zegerid overdose may include:Blurry vision, confusion, drowsiness, dry mouth, flushing, headache, nausea, rapid heartbeat, sweating, vomiting
  • Zegerid Prescribing Information (FDA)
  • Zegerid MedFacts Consumer Leaflet (Wolters Kluwer)
  • Zegerid Consumer Overview