Trade Names:Creon 5- Capsules, delayed-release 5,000 units lipase/18,750 units protease/16,600 units amylase
Trade Names:Creon 10- Capsules, delayed-release 10,000 units lipase/37,500 units protease/33,200 units amylase
Trade Names:Creon 20- Capsules, delayed-release 20,000 units lipase/75,000 units protease/66,400 units amylase
Trade Names:Kutrase- Capsules 2,400 units lipase/30,000 units protease/30,000 units amylase
Trade Names:Lipram-UL12- Capsules, delayed-release 12,000 units lipase/39,000 units protease/39,000 units amylase
Trade Names:Lipram-UL18- Capsules, delayed-release 18,000 units lipase/58,500 units protease/58,500 units amylase
Trade Names:Lipram-UL20- Capsules, delayed-release 20,000 units lipase/65,000 units protease/65,000 units amylase
Trade Names:Pancrease MT 4- Capsules 4,000 units lipase/12,000 units protease/12,000 units amylase
Trade Names:Pancrease MT 10- Capsules 10,000 units lipase/30,000 units protease/30,000 units amylase
Trade Names:Pancrease MT 16- Capsules 16,000 units lipase/48,000 units protease/48,000 units amylase
Trade Names:Pancrease MT 20- Capsules 20,000 units lipase/44,000 units protease/56,000 units amylase
Trade Names:Pancrecarb MS-4- Capsules, delayed-release 4,000 units lipase/25,000 units protease/25,000 units amylase
Trade Names:Pancrecarb MS-8- Capsules, delayed-release 8,000 units lipase/45,000 units protease/40,000 units amylase
Trade Names:Pancrelipase- Capsules 4,500 units lipase/25,000 units protease/20,000 units amylase- Tablets 8,000 units lipase/30,000 units protease/30,000 units amylase- Capsules 16,000 units lipase/48,000 units protease/48,000 units amylase- Tablets 16,000 units lipase/60,000 units protease/60,000 units amylase
Trade Names:Panokase- Tablets 8,000 units lipase/30,000 units protease/30,000 units amylase
Trade Names:Plaretase 8000- Tablets 8,000 units lipase/30,000 units protease/30,000 units amylase
Trade Names:Ultrase- Capsules 4,500 units lipase/25,000 units protease/20,000 units amylase
Trade Names:Ultrase MT 12- Capsules 12,000 units lipase/39,000 units protease/39,000 units amylase
Trade Names:Ultrase MT 18- Capsules 18,000 units lipase/58,500 units protease/58,500 units protease
Trade Names:Ultrase MT 20- Capsules 20,000 units lipase/65,000 units protease/65,000 units protease
Trade Names:Viokase- Powder 16,000 units lipase/60,000 units protease/60,000 units amylase
Trade Names:Viokase 8- Tablets 8,000 units lipase/30,000 units protease/30,000 units amylase
Trade Names:Viokase 16- Tablets 16,000 units lipase/60,000 units protease/60,000 units amylase
Cotazym (Canada)Creon 5 Minimicrospheres (Canada)Creon 10 Minimicrospheres (Canada)Creon 20 Minimicrospheres (Canada)Creon 25 Minimicrospheres (Canada)Helps to digest and absorb fats, proteins, and carbohydrates from food.
Enzyme replacement therapy in patients who do not produce enough pancreatic enzymes because of cystic fibrosis, chronic pancreatitis, postpancreatectomy, ductal obstructions caused by cancer of pancreas or common bile duct, pancreatic insufficiency; treatment of steatorrhea of malabsorption syndrome; postgastrectomy or after GI surgery; pancreatic function testing.
Hypersensitivity to pork protein or enzymes; acute pancreatitis; acute exacerbations of chronic pancreatic disease.
Dosage is adjusted based on severity of the exocrine pancreatic enzyme deficiency. Dosage recommendation varies with the brand and formulation. Take capsules or tablets with meals or snacks.
Pancrecarb , Ultrase , Ultrase MTAdultsPO Start with 1 or 2 capsules with each meal or snack.
KutraseAdultsPO Take 1 capsule with each meal or snack.
Pancrease MT 4Children (older than 4 yr of age)PO Start with 400 lipase units/kg/meal up to a max of 2,500 lipase units/kg/meal.
Children (younger than 4 yr of age)PO Start with 1,000 lipase units/kg with each meal up to a max of 2,500 lipase units with each meal.
Children (up to 12 mo of age)PO 2,000 to 4,000 lipase units per 120 mL of formula or breast milk.
PancrelipaseAdultsPO 4,000 to 20,000 lipase units with each meal and with snacks.
Children (7 to 12 yr of age)PO 4,000 to 12,000 lipase units with each meal and with snacks.
Children (1 to 6 yr of age)PO 4,000 to 8,000 lipase units with each meal and 4,000 units with each snack.
Children (6 mo to younger than 1 yr of age)PO 2,000 lipase units with each meal.
Creon 5Adults and Children (older than 6 yr of age)PO Usual starting dose is 2 to 4 capsules with each meal or snack.
Children (younger than 6 yr of age)PO Start with 1 to 2 capsules with each meal or snack. Select exact dose based on clinical experience with this age group.
Cystic fibrosis patientsPO Usual doses are 1,500 to 3,000 lipase units/kg with each meal (max, 6,000 lipase units/kg/meal).
Creon 10Adults and Children (older than 6 yr of age)PO Usual starting dose is 1 to 2 capsules with each meal or snack.
Children (younger than 6 yr of age)PO Usual starting dose is up to 1 capsule with each meal or snack.
Cystic fibrosis patientsPO Usual doses are 1,500 to 3,000 lipase units/kg with each meal (max, 6,000 lipase units/kg/meal).
Creon 20Adults and Children (older than 6 yr of age)PO Start with 1 capsule with each meal or snack.
Children (younger than 6 yr of age)PO Select exact dose based on clinical experience with this age group.
Cystic fibrosis patientsPO Usual starting doses are 1,500 to 3,000 lipase units/kg with each meal (max, 6,000 lipase units/kg/meal).
Panokase , Plaretase , Viokase (tablets)Cystic fibrosis and chronic pancreatitis patientsPO Dose ranges from 8,000 to 32,000 lipase units (1 to 4 tablets [ Plaretase , Panokase , Viokase 8 ] or 1 to 2 tablets [ Viokase 16 ]) with each meal.
Pancreatectomy or obstruction of pancreatic ductsPO 1 to 2 tablets ( Plaretase , Panokase , Viokase 8 ) or 1 tablet ( Viokase 16 ) every 2 h.
Viokase (powder)Cystic fibrosisPO 0.7 g (¼ tsp) with each meal.
Store at controlled room temperature (59° to 86°F) in tightly closed container. Protect from moisture.
Calcium carbonate or magnesium hydroxide may negate beneficial effect of enzymes.
IronSerum iron response to oral iron may be decreased with concomitant pancreatic enzyme administration.
None well documented.
Perianal irritation.
Colonic strictures; diarrhea; abdominal pain; intestinal obstruction; vomiting; intestinal stenosis; constipation; flatulence; nausea; bloating; cramping.
Hypersensitivity reaction.
Category B ( Pancrease MT ); Category C ( Creon , Kutrase , Pancrelipase , Panokase , Plaretase , Ultrase , Ultrase MT , Viokase ).
Undetermined.
Inhalation of airborne pancrelipase powder can precipitate asthma attack.
Colonic strictures reported primarily in cystic fibrosis patients often at dosages above the recommended range.
Contact of pancrelipase with skin can cause irritation.
Nausea, vomiting, abdominal cramps, diarrhea, hyperuricosuria, hyperuricemia.
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