Generic Name: olsalazine (ole SAL a zeen)Brand Names: Dipentum
Olsalazine affects substances in the body that cause inflammation, tissue damage, and diarrhea.
Olsalazine is used to treat ulcerative colitis.
Olsalazine may also be used for other purposes not listed in this medication guide.
Before taking olsalazine, tell your doctor if you have asthma or other allergies, kidney disease, or liver disease.Call your doctor at once if your colitis symptoms get worse, or if you have chest pain, shortness of breath, fast or pounding heartbeats, nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Before taking olsalazine, tell your doctor if you are allergic to any drugs, or if you have:
asthma or other allergies;
kidney disease; or
If you have any of these conditions, you may need a dose adjustment or special tests to safely take olsalazine.FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Olsalazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.Take olsalazine with a full glass of water. Store olsalazine at room temperature away from moisture and heat.
See also: Olsalazine dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include nausea, vomiting, and diarrhea.
Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using olsalazine.
Avoid getting a varicella (chickenpox) vaccine within 6 weeks after you stop taking olsalazine.
worsening colitis (fever, stomach pain, cramping, or bloody diarrhea);
chest pain, shortness of breath, fast or pounding heartbeats; or
nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
mild stomach discomfort;
skin rash, itching;
muscle or joint pain; or
urinating more often than usual.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Ulcerative Colitis -- Active:
500 mg - 1 g orally per day, given in 2 equally divided dosages. Alternatively, doses of 500 mg up to 4 times a day have been used in severe cases.
Usual Adult Dose for Ulcerative Colitis -- Maintenance:
500 mg orally twice a day.
Usual Adult Dose for Ankylosing Spondylitis:
Study (n=4)500 mg 2 times daily for one week, increased by 500 mg weekly to a maximum of 1 g 3 times daily, for a total of 6 months.
Usual Pediatric Dose for Ulcerative Colitis:
Study (n=56)Greater than or equal to 2 years: 30 mg/kg/day (maximum, 2 g/day), starting at 25% of calculated daily dose, and increasing by one dose every third day, to four doses per day.
The following drugs can interact with olsalazine. Tell your doctor if you are using any of these:
a blood thinner such as warfarin (Coumadin);
This list is not complete and there may be other drugs that can interact with olsalazine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.