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Drugs reference index «Nexterone Solution»

Nexterone Solution

Nexterone Solution

Generic Name: Amiodarone (A-mi-OH-da-rone)Brand Name: Nexterone

Nexterone Solution is used for:

Treating and preventing certain kinds of life-threatening heart rhythm problems in patients who cannot take the oral form of Nexterone Solution or who do not respond to other medicines. It may also be used for other conditions as determined by your doctor.

Nexterone Solution is an antiarrhythmic. It works by stabilizing the heart rhythm in conditions in which the heart is beating too fast or in an irregular rhythm. It is usually used in situations in which the abnormal heart rhythms, if not treated, could cause death.

Do NOT use Nexterone Solution if:

  • you are allergic to any ingredient in Nexterone Solution, including iodine
  • you have moderate to severe heart block (unless you have a pacemaker), very slow heartbeat, or shock due to serious heart problems
  • you are taking cisapride, dofetilide, certain H1 antagonists (eg, astemizole, terfenadine), nilotinib, certain phenothiazines (eg, thioridazine), a phosphodiesterase inhibitor (eg, vardenafil), ranolazine, a streptogramin (eg, quinupristin, dalfopristin), St. John's wort, tetrabenazine, or ziprasidone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Nexterone Solution:

Some medical conditions may interact with Nexterone Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have abnormal liver function tests or a history of liver problems, lung or breathing problems, other heart problems, low blood pressure, thyroid problems, electrolyte problems (eg, low blood potassium or magnesium), eye or vision problems, slow heartbeat, or heart block
  • if you have recently had severe or persistent diarrhea
  • if you will be having surgery, or if you have an implanted pacemaker or defibrillator

Some MEDICINES MAY INTERACT with Nexterone Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cisapride, dofetilide, certain H1 antagonists (eg, astemizole, terfenadine), certain phenothiazines (eg, thioridazine), nilotinib, phosphodiesterase inhibitors (eg, vardenafil), ranolazine, St. John's wort, streptogramins (eg, dalfopristin, quinupristin), tetrabenazine, or ziprasidone because the risk of worsening irregular heartbeat may be increased
  • Many prescription and nonprescription medicines (eg, used for allergies, bacterial and fungal infections, blood thinning, cancer, cough, enlarged prostate, heartburn or reflux disease, heart problems, high blood pressure, high cholesterol, HIV infection, immune system suppression, inflammation, irregular heartbeat, local anesthesia, mental or mood problems, nausea and vomiting, pain, seizures), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may interact with Nexterone Solution, increasing the risk of serious side effects. Check with your doctor to see if Nexterone Solution may interact with any other medicine that you are taking

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nexterone Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nexterone Solution:

Use Nexterone Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Nexterone Solution will be given by a qualified health care provider who is experienced in treating life-threatening irregular heartbeats. Nexterone Solution is usually given as an injection at your doctor's office, hospital, or clinic.
  • Do not use Nexterone Solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Do not eat grapefruit or drink grapefruit juice while you use Nexterone Solution.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Nexterone Solution, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Nexterone Solution.

Important safety information:

  • Nexterone Solution may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Nexterone Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Nexterone Solution may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Nexterone Solution stays in your body for weeks or months even after you stop taking it. Use caution during treatment with Nexterone Solution and for several months after you stop taking it if you are taking any medicines that may interact with it.
  • Limit alcoholic beverages while taking Nexterone Solution.
  • Tell your doctor or dentist that you take Nexterone Solution before you receive any medical or dental care, emergency care, or surgery.
  • Tell your doctor if you have severe or persistent diarrhea while you are using Nexterone Solution. You will need to take care not to become dehydrated.
  • Worsening of irregular heartbeat, life-threatening lung disease, and serious liver problems may occur with Nexterone Solution. Therefore, it should only be given to patients with life-threatening heartbeats who cannot tolerate other medicines.
  • Your doctor may want you to check your pulse rate every day while you take Nexterone Solution. Learn how to monitor your pulse.
  • Carry an ID card at all times that says you use Nexterone Solution.
  • Lab tests, including electrocardiogram (ECG), chest x-rays, lung tests, liver tests, thyroid tests, and eye exams, may be performed while you use Nexterone Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Nexterone Solution with caution in the ELDERLY; they may be more sensitive to its effects, especially slow heartbeat.
  • Nexterone Solution should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Nexterone Solution has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Nexterone Solution while you are pregnant. Nexterone Solution is found in breast milk. Do not breast-feed while taking Nexterone Solution.

Possible side effects of Nexterone Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; confusion; coughing up blood; dark urine; decreased urination; fainting; feeling of being unusually cold; fever, chills, or persistent sore throat; joint pain; mental or mood changes; muscle pain, tenderness, or weakness (especially with fever or unusual tiredness); numbness of an arm or leg; red, swollen, blistered, or peeling skin; severe dizziness; severe stomach pain; shortness of breath; slow heartbeat; sudden unexplained weight change; swelling of the hands or feet; symptoms of thyroid problems (eg, feeling of being unusually hot or cold, increased sweating, mental or mood changes, unusual weight changes, numbness or tingling of the hands or feet, menstrual changes); unusual bruising or bleeding; unusual cough; vision changes (eg, seeing halos, blurred vision, loss of vision); wheezing; worsening of irregular heartbeat; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include fainting; lightheadedness, especially upon standing; severe dizziness; slow or irregular heartbeat; weakness; yellowing of the skin or eyes.

Proper storage of Nexterone Solution:

Nexterone Solution is usually handled and stored by a health care provider. If you are using Nexterone Solution at home, store Nexterone Solution as directed by your pharmacist or health care provider. Keep Nexterone Solution out of the reach of children and away from pets.

General information:

  • If you have any questions about Nexterone Solution, please talk with your doctor, pharmacist, or other health care provider.
  • Nexterone Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Nexterone Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Nexterone Consumer Overview
  • Amiodarone Prescribing Information (FDA)
  • Amiodarone Professional Patient Advice (Wolters Kluwer)
  • amiodarone Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
  • Cordarone Advanced Consumer (Micromedex) - Includes Dosage Information
  • Cordarone Prescribing Information (FDA)
  • Pacerone Prescribing Information (FDA)