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Drugs reference index «loteprednol etabonate and tobramycin Ophthalmic»

loteprednol etabonate and tobramycin Ophthalmic

loteprednol etabonate and tobramycin (Ophthalmic route)

loe-te-PRED-nol et-a-BOE-nate, toe-bra-MYE-sin

Commonly used brand name(s):

In the U.S.

  • Zylet

Available Dosage Forms:

  • Suspension

Therapeutic Class: Aminoglycoside/Corticosteroid Combination

Pharmacologic Class: Loteprednol

Chemical Class: Aminoglycoside

Uses For loteprednol etabonate and tobramycin

Loteprednol and tobramycin is a combination of an antibiotic and a corticosteroid. It is used in the eye to prevent permanent damage, which may occur with certain eye problems.

loteprednol etabonate and tobramycin is available only with your doctor's prescription.

Before Using loteprednol etabonate and tobramycin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For loteprednol etabonate and tobramycin, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to loteprednol etabonate and tobramycin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Studies on loteprednol etabonate and tobramycin have been done only in adult patients, and there is no specific information comparing use of loteprednol and tobramycin in children with use in other age groups.


loteprednol etabonate and tobramycin has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.


Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using loteprednol etabonate and tobramycin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alcuronium
  • Atracurium
  • Cidofovir
  • Cisatracurium
  • Decamethonium
  • Doxacurium
  • Fazadinium
  • Gallamine
  • Hexafluorenium
  • Lysine
  • Metocurine
  • Mivacurium
  • Pancuronium
  • Pipecuronium
  • Rapacuronium
  • Rocuronium
  • Succinylcholine
  • Tacrolimus
  • Tubocurarine
  • Vecuronium

Using loteprednol etabonate and tobramycin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cisplatin
  • Cyclosporine
  • Furosemide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of loteprednol etabonate and tobramycin. Make sure you tell your doctor if you have any other medical problems, especially:

  • Cataract surgery—Use of loteprednol after cataract surgery may delay healing and increase the chance of side effects
  • Certain eye diseases that cause the cornea to get thin—Use of ophthalmic loteprednol could cause a hole to form (perforation)
  • Fungus infection of the eye or
  • Herpes infection of the eye or
  • Pussy conditions of the eye or
  • Virus infection of the eye or
  • Yeast infection of the eye—Ophthalmic loteprednol and tobramycin may mask or make existing infections worse.
  • Glaucoma—Prolonged use of corticosteroids may result in glaucoma; caution should be used when corticosteroids are used in patients who have glaucoma

Proper Use of loteprednol etabonate and tobramycin

Shake the container very well before applying the eye drops.

Using only if the imprinted neckband is intact.

Do not wear soft contact lenses while you are using loteprednol etabonate and tobramycin..

Decrease use gradually as symptoms improve.

To help clear up your eye infection completely, keep using loteprednol and tobramycin for the full time of treatment, even if your symptoms have disappeared.

To use:

  • First, wash your hands. Tilt your head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye.
  • If you think you did not get the drop of medicine into your eye properly, use another drop.
  • To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed.


The dose of loteprednol etabonate and tobramycin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of loteprednol etabonate and tobramycin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For ophthalmic suspension dosage form (eye drops):
    • For eye disorders:
      • Adults—Use one or two drops into the affected eye every four to six hours. Your doctor may have you use the drops more frequently during the first day or two and will probably have you space the doses further apart as the eye gets better
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of loteprednol etabonate and tobramycin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store upright.

Precautions While Using loteprednol etabonate and tobramycin

If you will be using loteprednol etabonate and tobramycin for more than few weeks, an ophthalmologist (eye doctor) should examine your eyes at regular visits to make sure it does not cause unwanted effects.

If your eye infection does not improve or if your condition becomes worse, check with your doctor.

loteprednol etabonate and tobramycin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Increased intraocular pressure
  • painful irritation of the clear front part of the eye
Less common
  • Blurred vision or blue-green halos seen around objects
  • blurred vision or other changes in vision
  • decreased vision
  • discharge from the eye
  • dry eyes
  • eyelid burning, redness, itching, pain, or tenderness
  • fast heartbeat
  • fever
  • hives
  • hoarseness
  • irritation and swelling of the eye
  • itching
  • joint pain
  • lid itching and swelling
  • pain in eye
  • rash
  • redness of skin
  • redness of eyelid
  • sensitivity of eyes to light
  • shortness of breath
  • stiffness or swelling
  • swelling of eyelids, face, lips, hands, or feet
  • tightness in chest
  • troubled breathing or swallowing
  • wheezing
Incidence not known
  • Redness of eye
  • tearing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Burning
  • dry eyes
  • headache
  • increased sensitivity of eyes to light
  • itching
  • stinging

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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