Trade Names:Claritin-D 12 Hour- Tablets 120 mg pseudoephedrine sulfate and 5 mg loratadine
Trade Names:Claritin-D 24 Hour- Tablets 240 mg pseudoephedrine sulfate and 10 mg loratadineClaritin Allergy and Sinus (Canada)Claritin Allergy and Sinus Extra Strength (Canada)
Competitively antagonizes histamine at the H 1 receptor.Pseudoephedrine
Causes vasoconstriction and subsequent shrinkage of nasal mucous membranes by alpha-adrenergic stimulation, promoting nasal drainage.
Relief of symptoms of seasonal allergic rhinitis.
Hypersensitivity to any ingredient of product; patients with narrow-angle glaucoma, urinary retention, severe hypertension, or severe coronary artery disease; MAOI therapy or within 14 days of stopping MAOI; idiosyncratic reactions to adrenergic agents.
PO 1 tablet every day ( Claritin-D 24 Hour ) or 1 tablet bid ( Claritin-D 12 Hour ).
Store tablets at controlled room temperature (59° to 77°F). Keep container tightly closed. Protect unit-dose hospital pack from light.
May increase loratadine plasma levels.Pseudoephedrine Antihypertensive agents that interfere with sympathetic activity (eg, beta-blockers, mecamylamine, methyldopa, reserpine, veratrum alkaloids)
Antihypertensive effect of these agents may be reduced.Digitalis
Increased ectopic pacemaker activity may occur.MAOIs
Contraindicated in patients taking MAOIs and for 14 days after stopping use of an MAOI.
May diminish or prevent positive reactions to skin tests.
Hypertension; hypotension; palpitations; peripheral edema; syncope; tachycardia; ventricular extrasystoles.
Headache (19% for 12-h tablet); insomnia (16% for 12-h tablet; 5% for 24-h tablet); somnolence (approximately 7%); nervousness, dizziness, fatigue (approximately 4%); aggressive reaction; agitation; anxiety; apathy; confusion; convulsions; decreased libido; depression; dysphonia; emotional lability; euphoria; hyperkinesia; hypertonia; impaired concentration; irritability; migraine; paresthesia; paroniria; tremors; vertigo.
Acne; bacterial skin infection; dry skin; eczema; epidermal necrolysis; erythema; flushing; hematoma; increased sweating; pruritus; rash; urticaria.
Pharyngitis (approximately 4%); abnormal lacrimation; abnormal vision; blurred vision; conjunctivitis; earache; ear infection; eye pain; mydriasis; photophobia; tinnitus.
Dry mouth (14% for 12-h tablet; 8% for 24-h tablet); nausea (3%); anorexia (2%); dyspepsia (3% for 12-h tablet); abdominal distension, distress, pain; altered taste; constipation; diarrhea; eructation; flatulence; gastritis; gingival bleeding; hemorrhoids; increased appetite; stomatitis; taste loss; tongue discoloration; tongue ulceration; toothache; vomiting.
Dysmenorrhea (2%); dysuria; impotence; intermenstrual bleeding; micturition frequency; nocturia; oliguria; polyuria; urinary retention; UTI; vaginitis.
Cholelithiasis; hepatic function abnormal.
Dehydration; edema; thirst; weight gain.
Coughing (3%); bronchitis; bronchospasm; chest congestion; dry throat; dyspnea; epistaxis; halitosis; hemoptysis; nasal congestion; nasal irritation; pleurisy; pneumonia; sinusitis; sneezing; sputum increased; upper respiratory infection; wheezing.
Thirst (2%); abscess; arthralgia; asthenia; back pain; chest pain; facial edema; fever; flu-like symptoms; hypoesthesia; leg cramps; lymphadenopathy; malaise; musculoskeletal pain; myalgia; rigors; tendinitis; torticollis; viral infection.
Category B .
Excreted in breast milk.
Safety and efficacy not established in children younger than 12 yr of age.
Use with caution in patients with hypertension, hyperthyroidism, diabetes, cardiovascular disease, increased intraocular pressure, renal impairment, hepatic impairment, or prostatic hypertrophy.
Esophageal obstruction and perforation has been reported with product; therefore, should not be used by patients with history of difficulty in swallowing tablets or who have known upper GI narrowing or abnormal esophageal peristalsis.
May cause CNS stimulation with convulsions or cardiovascular collapse with accompanying hypotension.
Somnolence, tachycardia, headache, giddiness, nausea, vomiting, sweating, thirst, precordial pain, palpitations, difficulty in micturition, muscular weakness and tenseness, anxiety, restlessness, insomnia, toxic psychosis with delusions and hallucinations, cardiac arrhythmias, circulatory collapse, convulsions, coma, respiratory failure.
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