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Drugs reference index «Hycamtin Capsules»

Hycamtin Capsules

Generic Name: Topotecan (TOE-poe-TEE-kan)Brand Name: Hycamtin

Hycamtin Capsules may cause severe and sometimes fatal bone marrow suppression and blood problems. These blood problems may increase the risk of developing a severe infection. Hycamtin Capsules should not be used in patients who have low platelet levels or very low white blood cell levels. Contact your doctor at once if you have symptoms of an infection (eg, fever, chills, persistent sore throat, painful urination), unusual bruising or bleeding, or unusual fatigue. Frequent blood tests will be performed to monitor for side effects. Be sure to keep all doctor and lab appointments.

Hycamtin Capsules are used for:

Treating small cell lung cancer in certain patients.

Hycamtin Capsules are an antineoplastic. It works by killing certain cancer cells.

Do NOT use Hycamtin Capsules if:

  • you are allergic to any ingredient in Hycamtin Capsules
  • you are pregnant, planning to become pregnant, or are breast-feeding
  • you have severe bone marrow problems, low platelets, or very low blood cell counts

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hycamtin Capsules:

Some medical conditions may interact with Hycamtin Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney problems, bone marrow problems, or blood problems
  • if you have a history of lung problems (eg, interstitial lung disease [ILD], pulmonary fibrosis, lung cancer) or if your chest area has been exposed to radiation
  • if you have recently received a live vaccine

Some MEDICINES MAY INTERACT with Hycamtin Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Medicines that may harm the lungs (eg, certain antiarrhythmics, certain antibiotics, amphotericin B, certain cancer drugs) because the risk of serious lung problems may be increased. Ask your doctor if you are unsure if any of your medicines might harm the lungs.
  • Carboplatin, cisplatin, granulocyte colony-stimulating factor (G-CSF), or other antineoplastic medicines because the risk or duration of severe bone marrow or blood problems may be increased
  • P-glycoprotein inhibitors (eg, cyclosporine A, elacridar, ketoconazole, ritonavir, saquinavir) because they may increase the risk of Hycamtin Capsules's side effects
  • Hydantoins (eg, phenytoin) because they may decrease Hycamtin Capsules's effectiveness
  • Live vaccines (eg, measles, mumps) because the risk of their side effects may be increased by Hycamtin Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hycamtin Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hycamtin Capsules:

Use Hycamtin Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Hycamtin Capsules. Talk to your pharmacist if you have questions about this information.
  • Take Hycamtin Capsules by mouth with or without food.
  • Swallow Hycamtin Capsules whole. Do not break, crush, or chew before swallowing.
  • Take Hycamtin Capsules with a full glass of water (8 oz/240 mL).
  • If you miss a dose of Hycamtin Capsules or if you vomit after you take a dose, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Hycamtin Capsules.

Important safety information:

  • Hycamtin Capsules may cause tiredness or weakness during treatment and for several days after treatment. These effects may be worse if you take it with alcohol or certain medicines. Use Hycamtin Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Hycamtin Capsules may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Hycamtin Capsules may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Some patients taking Hycamtin Capsules have developed severe and sometimes fatal lung problems. The risk may be greater if you have a history of certain lung problems or if your chest area has been exposed to radiation. it may also be greater if you take certain other medicines. Tell your doctor right away if you develop a cough, fever, shortness of breath, blue or unusually pale skin or nails, or chest pain.
  • If nausea, vomiting, diarrhea, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking Hycamtin Capsules. Talk with your doctor before you receive any vaccine.
  • Do not touch broken or leaking capsules. If you get Hycamtin Capsules on your skin, wash it off right away with soap and water. Contact your doctor if you experience a skin reaction. Talk with your doctor about how to dispose of broken or leaking capsules.
  • Do not get Hycamtin Capsules in your eyes. If you get it in your eyes, rinse with cool water for 15 minutes and contact your doctor.
  • If you may become pregnant, you must use an effective form of birth control while you take Hycamtin Capsules. If you have questions about effective birth control, talk with your doctor.
  • Lab tests, including complete blood cell counts, may be performed while you use Hycamtin Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Hycamtin Capsules with caution in the ELDERLY; they may be more sensitive to its effects.
  • Hycamtin Capsules should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Hycamtin Capsules if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Hycamtin Capsules are found in breast milk. Do not breast-feed while taking Hycamtin Capsules.

Possible side effects of Hycamtin Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; fatigue; hair loss; loss of appetite; nausea; stomach pain; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue or unusually pale skin or nails; chest pain; fever, chills, or persistent sore throat; painful or burning urination; severe or persistent cough; severe or persistent diarrhea, stomach pain, or cramps; severe or persistent tiredness or weakness; shortness of breath; swelling or soreness of the mouth or tongue; unusual or unexplained bruising or bleeding; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Hycamtin Capsules:

Store Hycamtin Capsules in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C) in the original container. Do not freeze. Store away from heat, moisture, and light. Keep Hycamtin Capsules out of the reach of children and away from pets.

General information:

  • If you have any questions about Hycamtin Capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Hycamtin Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hycamtin Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Hycamtin Prescribing Information (FDA)
  • Hycamtin Concise Consumer Information (Cerner Multum)
  • Hycamtin Advanced Consumer (Micromedex) - Includes Dosage Information