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Drugs and diseases reference index

Diseases reference index «Macroamylasemia»


Macroamylasemia is the presence of an abnormal substance called macroamylase in the blood.


Macroamylase is a substance that consists of an enzyme, called amylase, attached to a protein. Because it is large, macroamylase is filtered very slowly from the blood by the kidneys.

Most people with macroamylasemia have no serious underlying disorder, but the condition has been associated with:

  • Celiac disease
  • Lymphoma
  • HIV infection
  • Monoclonal gammopathy
  • Rheumatoid arthritis
  • Ulcerative colitis


Macroamylasemia does not cause symptoms.

Exams and Tests

A blood test will show high levels of amylase. However, macroamylasemia can be confused with acute pancreatitis, which also causes high levels of amylase in the blood.

Macroamylasemia can be diagnosed by measuring amylase levels in the urine. Urine levels of amylase are low. (Urine amylase levels are high in patients with acute pancreatitis.)