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Drugs and diseases reference index

Definition of «SV40»

SV40: Simian virus 40, a polyomavirus found in simians (nonhuman primates), SV40 has no relationship to the human immunodeficiency virus (HIV) or to the simian immunodeficiency virus (SIV).

Some lots of polio vaccines in the 1960s were discovered to contain SV40. It was found in the inactivated (Salk) polio vaccine and some experimental lots of oral (Sabin) polio vaccine. The vaccine in those lots had been manufactured in kidney cells from simians (monkeys) that harbored SV40. The control methods used before this time did not identify this adventitious agent. The formalin inactivation process used to kill the poliovirus was found not to inactivate the SV40 completely. Since 1961, manufacturers have been required to test for SV 40. A few years later, the source of monkeys used for production was changed to species that do not harbor SV40.

There is limited evidence that SV40 can infect humans, but there is no evidence it causes human health problems and there is specifically no evidence that exposure to SV40 is associated with cancer in humans.

For More Information «SV40»

  • SV40 Cancer Foundation

    SV40 stands for Simian Virus 40. SV40 was the 40th virus found in rhesus monkey kidney cells when these cells were used to make the polio vaccine.

  • NIP: Vacsafe/Concerns/Cancer/SV40, polio, and cancer

    Vaccine Safety: Questions answered about Simian Virus 40 (SV40), Polio Vaccine, and Cancer

  • SV40 - Vaccine information

    www.sfgate.com/cgi-bin/article.cgi?file=/chronicle/archive/2001/07/15 /MN193825.DTL. Rogue virus in the vaccine: Early polio vaccine harbored virus now feared to cause ...

  • SV40: Facts, Discussion Forum, and Encyclopedia Article

    SV40 is an abbreviation for Simian vacuolating virus 40 or Simian virus 40, a polyomavirus. that is found in both monkey. s and human. s. Like other polyomaviruses, SV40 is a ...

  • SV40-Cancer-Polio Vaccine Link

    This is an excerpt from: Simian Virus 40 (SV40): A Cancer Causing Monkey Virus from FDA-Approved Vaccines. Michael E. Horwin, M.A., J.D. * This article was originally published ...