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Felty syndrome: A complication of long-standing rheumatoid arthritis characterized by the presence of 3 conditions -- rheumatoid arthritis, an enlarged spleen (splenomegaly), and an abnormally low white blood cell count. The white blood cells that are low are called granulocytes (or neutrophils).
Felty syndrome predisposes to infections such as pneumonia or skin infections, because of the low white counts. Ulcers in the skin over the legs can also complicate Felty's syndrome. The cause of the syndrome is not known. White cells may be stored excessively in the spleen. especially in patients with Felty's syndrome who have antibodies against granulocytes.
In Felty syndrome, the underlying rheumatoid arthritis is managed in the standard manner. Patients with severe infectious disease may benefit from weekly injections of granulocyte colony stimulating factor (G-CSF) to stimulate the production of granulocytes.
The syndrome was named for the American physician Augustus Roi Felty (1895-1964) who first described it in 1924 at Johns Hopkins Hospital.
Read about the conditions of Felty's syndrome (rheumatoid arthritis, an enlarged spleen, an abnormally low white blood count), its symptoms and treatment.
Felty syndrome (FS), which was first described in 1924, is a potentially serious condition that is associated with seropositive (rheumatoid factor [RF ...
Felty syndrome is a rare disorder that involves rheumatoid arthritis, a swollen spleen, decreased white blood cell count, and repeated infections. Causes ...
The cause of Felty syndrome is unknown. It is more common in people who have had rheumatoid arthritis for a long time. People with this syndrome are at risk of ...
List of 5 disease causes of Felty syndrome, patient stories, diagnostic guides. Diagnostic checklist, medical tests, doctor questions, and related signs or ...