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FAS gene: A gene that encodes one of several proteins important to apoptosis, the normal process through which cells die. Mutations in the FAS gene have been found in ALPS (the autoimmune lymphoproliferative syndrome), a disease in which there is failure of lymphocytes to die on schedule. As a result, lymphocytes stay about and attack the body's own tissues, a condition known as autoimmunity. Mutations in FAS account for about 83% of cases of ALPS.
The FAS gene is on chromosome 10q24.1. The gene is member 6 of the tumor necrosis factor receptor superfamily. FAS is now officially known as TNFRSF6. It has also confusingly been known as APO-1, APT1, and CD95.
Complete information for FAS gene (protein-coding), Fas (TNF receptor superfamily, member 6)
FAS gene: A gene that encodes one of several proteins important to apoptosis, the normal process through which cells die. Mutations in the FAS gene have been found in ALPS ...
The official name of this gene is “Fas (TNF receptor superfamily, member 6).†FAS is the gene's official symbol. The FAS gene is also known by other names ...
Official Symbol FAS provided by HGNC Official Full Name Fas (TNF receptor superfamily, member 6) provided by HGNC
Top of page Abstract. To clarify whether Fas and Fas ligand (FasL) mutations are involved in the pathogenesis of Hashimoto's thyroiditis (HT), we examined the open reading ...