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Dihydroorotate dehydrogenase: An enzyme necessary to pyrimidine synthesis and therefore essential to the production of DNA and RNA. The drug leflunomide (Arava), an immunomodulatory agent, acts by specifically inhibiting dihydroorotate dehydrogenase.
Dihydroorotate dehydrogenase is an enzyme. that catalyzes the fourth step in the de novo biosynthesis of pyrimidine. It converts dihydroorotate to orotate:
Dihydroorotate dehydrogenase (DHODH) catalyzes the conversion of dihydroorotate to orotate which corresponds to the fourth reaction step within pyrimidine de novo ...
Infect Disord Drug Targets. Author manuscript; available in PMC 2010 June 10.
Featured Image. Picture of Psoriasis. A reddish, scaly rash often located over the surfaces of the elbows, knees, scalp, and around or in the ears, navel, genitals or buttocks...
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