Generic Name: fenofibric acid (FEN oh FYE brik AS id)Brand Names: Fibricor, Trilipix
Fenofibric acid helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).
Fenofibric acid is used to treat high cholesterol and high triglyceride levels. It is sometimes given together with other cholesterol-lowering medications.
Fenofibric acid may also be used for other purposes not listed in this medication guide.
You should not use fenofibric acid if you have liver disease, gallbladder disease, severe kidney disease (or if you are on dialysis), or if you are breast-feeding a baby.
Before you take fenofibric acid, tell your doctor if you have kidney disease, diabetes, or underactive thyroid.
Fenofibric acid is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.Avoid drinking alcohol while taking fenofibric acid. Alcohol can raise triglyceride levels, and may also damage your liver while you are taking fenofibric acid.
Avoid eating foods that are high in fat or cholesterol. Fenofibric acid will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.In rare cases, fenofibric acid can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine.
You should not use fenofibric acid if you have:
gallbladder disease; or
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take fenofibric acid:
Take fenofibric acid exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor. Follow the directions on your prescription label.Take the medicine with a full glass of water.
You may take fenofibric acid with or without food.
If you also take cholestyramine (Questran), colesevelam (Welchol), or colestipol (Colestid), take these medicines at least 1 hour after taking fenofibric acid, or 4 to 6 hours before taking fenofibric acid. Do not take any of these medicines at the same time you take fenofibric acid.
"Statin" cholesterol-lowering medications may be taken at the same time as fenofibric acid.
Fenofibric acid is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.
To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.
To be sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney, liver, and gallbladder function may also need to be tested. Do not miss any scheduled visits to your doctor.Store fenofibric acid at room temperature away from moisture and heat.
See also: Fenofibric acid dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Avoid eating foods that are high in fat or cholesterol. Fenofibric acid will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.Avoid drinking alcohol while taking fenofibric acid. Alcohol can raise triglyceride levels, and may also damage your liver while you are taking fenofibric acid.
sharp stomach pain spreading to your back or shoulder blade;
stomach pain just after eating a meal;
nausea, vomiting, fever, clay-colored stools, jaundice (yellowing of the skin or eyes);
pain or swelling in one or both legs; or
chest pain, sudden cough, wheezing, rapid breathing, fast heart rate.
Less serious side effects may include:
joint pain, mild back pain;
runny or stuffy nose, sore throat; or
diarrhea, constipation, bloating, indigestion.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Hyperlipidemia:
The following adult dose recommendations are only for fenofibric acid marketed as the trade name Trilipix (TM):Mixed Dyslipidemia treatment therapy co-administered with an HMG-CoA reductase inhibitor (statin): 135 mg orally daily. For convenience, the daily dose may be taken at the same time as a statin, according to the dosing recommendations for each medication. Co-administration with the maximum dose of a statin has not been evaluated in clinical studies and should be avoided unless the benefits are expected to outweigh the risks.Severe Hypertriglyceridemia: Initial dose: 45 to 135 mg orally once daily. Maintenance dose: Dosage should be individualized according to patient response, and adjusted if needed following repeat lipid determinations at 4 to 8 week intervals. Maximum dose: 135 mg orally once daily\tPrimary Hyperlipidemia or Mixed Dyslipidemia: 135 mg orally once dailyThe following adult dose recommendations are only for fenofibric acid marketed as the trade name Fibricor (TM):Periodic determination of serum lipids should be obtained during initial therapy in order to establish the lowest effective dose of fenofibric acid. Therapy should be withdrawn in patients who do not have an adequate response after 2 months of treatment with the maximum recommended dose of 105 mg daily.Primary Hyperlipidemia or Mixed Dyslipidemia: 105 mg orally once dailySevere Hypertriglyceridemia: Initial dose: 35 to 105 mg orally daily. Maintenance: Dosage should be individualized according to patient response, and should be adjusted if necessary following repeat lipid determinations at 4 to 8 week intervals. Maximum: 105 mg orally daily
Tell your doctor about all other medications you use, especially:
cyclosporine (Neoral, Sandimmune, Gengraf); or
a blood thinner such as warfarin (Coumadin);
a diuretic (water pill);
birth control pills or hormone replacement therapy; or
a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others.
This list is not complete and there may be other drugs that can interact with fenofibric acid. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.