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Drugs reference index «Entacapone»


Generic Name: Entacapone (en-TAK-a-pone)Brand Name: Comtan

Entacapone is used for:

Treating Parkinson disease when used with levodopa/carbidopa.

Entacapone is a catechol-o-methyltransferase (COMT) inhibitor. It works by increasing the levels of levodopa/carbidopa in the brain, enhancing its effectiveness.

Do NOT use Entacapone if:

  • you are allergic to any ingredient in Entacapone
  • you have taken certain monoamine oxidase inhibitors (MAOIs) (eg, phenelzine, tranylcypromine) within the past 14 days.

Contact your doctor or health care provider right away if any of these apply to you.

Before using Entacapone :

Some medical conditions may interact with Entacapone . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver disease or a history of a severe muscle problem called rhabdomyolysis

Some MEDICINES MAY INTERACT with Entacapone . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Ampicillin, chloramphenicol, cholestyramine, erythromycin, MAOIs (eg, phenelzine, selegiline, tranylcypromine), probenecid, or rifampicin because they may increase the risk of Entacapone 's side effects
  • Apomorphine, bitolterol, dobutamine, dopamine, isoetharine, isoproterenol, methyldopa, or sympathomimetics (eg, epinephrine) because their actions and the risk of their side effects may be increased by Entacapone

This may not be a complete list of all interactions that may occur. Ask your health care provider if Entacapone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Entacapone :

Use Entacapone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Entacapone may be taken with or without food.
  • Entacapone should be given each time a dose of levodopa/carbidopa is given.
  • If you miss a dose of Entacapone , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Entacapone .

Important safety information:

  • Entacapone may cause dizziness and drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Entacapone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Entacapone may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
  • Using Entacapone alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Entacapone ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Entacapone may cause nausea, especially when you first start to take it. Check with your doctor if nausea persists or is severe.
  • You may experience an increase in involuntary movements while taking Entacapone . Check with your doctor if this occurs.
  • Some people have experienced new, unusual, or increased urges (eg, gambling, sexual urges) while using Entacapone . Tell your doctor right away if you notice such effects.
  • Patients with Parkinson disease may have an increased risk of developing a certain type of skin cancer (melanoma). It is not known if Entacapone also increases the risk of melanoma. You may need to have skin exams while you are using Entacapone . Discuss any questions or concerns with your doctor.
  • Entacapone may color the urine a brownish orange. This is normal and is not a cause for concern.
  • Tell your doctor or dentist that you take Entacapone before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests may be performed to check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Entacapone while you are pregnant. It is not known if Entacapone is found in breast milk. If you are or will be breast-feeding while you use Entacapone , check with your doctor. Discuss any possible risks to your baby.

Do not stop taking Entacapone suddenly. If therapy is stopped, it should be tapered gradually.

Possible side effects of Entacapone :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in the color of urine; constipation; diarrhea; dizziness; drowsiness; dry mouth; nausea; stomach pain; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; fainting; fever; hallucinations; mental or mood changes; muscle pain, stiffness, or rigidity; severe or persistent dizziness; severe or persistent nausea or diarrhea; shortness of breath; uncontrolled muscle movements; unusual skin growths or change in the appearance of a mole.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include loose stools; stomach pain.

Proper storage of Entacapone :

Store Entacapone at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Entacapone out of the reach of children and away from pets.

General information:

  • If you have any questions about Entacapone , please talk with your doctor, pharmacist, or other health care provider.
  • Entacapone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Entacapone . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Entacapone Professional Patient Advice (Wolters Kluwer)
  • Entacapone Detailed Consumer Information (PDR)
  • entacapone Advanced Consumer (Micromedex) - Includes Dosage Information
  • entacapone Concise Consumer Information (Cerner Multum)
  • Comtan Prescribing Information (FDA)

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