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Drugs reference index «enalapril and hydrochlorothiazide»

enalapril and hydrochlorothiazide


enalapril and hydrochlorothiazide (Oral route)

en-AL-a-pril MAL-ee-ate, hye-droe-klor-oh-THYE-a-zide

Oral routeTablet

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, enalapril maleate/hydrochlorothiazide should be discontinued as soon as possible .

ACE inhibitors can cause injury or death to the developing fetus when used during the second and third trimesters. Stop therapy as soon as possible when pregnancy is detected .

Commonly used brand name(s):

In the U.S.

  • Vaseretic

Available Dosage Forms:

  • Tablet

Therapeutic Class: ACE Inhibitor/Thiazide Combination

Pharmacologic Class: Enalapril

Chemical Class: Thiazide

Uses For enalapril and hydrochlorothiazide

Enalapril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Enalapril works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax. Hydrochlorothiazide works by helping reduce the amount of salt and water in the body by acting on the kidneys to increase the flow of urine. Both of these medicines lower blood pressure and increase the supply of blood and oxygen to the heart .

enalapril and hydrochlorothiazide is available only with your doctor's prescription .

Before Using enalapril and hydrochlorothiazide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For enalapril and hydrochlorothiazide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to enalapril and hydrochlorothiazide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of enalapril and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of enalapril and hydrochlorothiazide combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment of dose in patients receiving enalapril and hydrochlorothiazide combination .

Pregnancy

Pregnancy CategoryExplanation
1st TrimesterCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd TrimesterDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.
3rd TrimesterDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using enalapril and hydrochlorothiazide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Dofetilide

Using enalapril and hydrochlorothiazide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetyldigoxin
  • Allopurinol
  • Amiloride
  • Arsenic Trioxide
  • Azathioprine
  • Canrenoate
  • Deslanoside
  • Digitalis
  • Digitoxin
  • Digoxin
  • Droperidol
  • Eplerenone
  • Flecainide
  • Interferon Alfa-2a
  • Ketanserin
  • Levomethadyl
  • Lithium
  • Metildigoxin
  • Ouabain
  • Potassium
  • Proscillaridin
  • Sotalol
  • Spironolactone
  • Triamterene

Using enalapril and hydrochlorothiazide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Acemetacin
  • Alacepril
  • Alclofenac
  • Aliskiren
  • Apazone
  • Aspirin
  • Azosemide
  • Bemetizide
  • Benazepril
  • Bendroflumethiazide
  • Benoxaprofen
  • Benzthiazide
  • Bepridil
  • Bromfenac
  • Bufexamac
  • Bumetanide
  • Bupivacaine
  • Buthiazide
  • Calcium Carbonate
  • Capsaicin
  • Captopril
  • Carbamazepine
  • Carprofen
  • Celecoxib
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Cholestyramine
  • Cilazapril
  • Clometacin
  • Clomipramine
  • Clonixin
  • Clopamide
  • Cyclopenthiazide
  • Cyclophosphamide
  • Cyclothiazide
  • Delapril
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Droxicam
  • Enalaprilat
  • Enalapril Maleate
  • Ethacrynic Acid
  • Etodolac
  • Etofenamate
  • Felbinac
  • Fenbufen
  • Fenoprofen
  • Fentiazac
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fosinopril
  • Furosemide
  • Ginkgo
  • Glipizide
  • Gold Sodium Thiomalate
  • Gossypol
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Ibuprofen
  • Imidapril
  • Indapamide
  • Indomethacin
  • Indoprofen
  • Isoxicam
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Lisinopril
  • Lornoxicam
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Metformin
  • Methyclothiazide
  • Metolazone
  • Moexipril
  • Nabumetone
  • Naproxen
  • Nesiritide
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Pentopril
  • Perindopril
  • Phenylbutazone
  • Pirazolac
  • Piretanide
  • Piroxicam
  • Pirprofen
  • Polythiazide
  • Propyphenazone
  • Proquazone
  • Quinapril
  • Quinethazone
  • Ramipril
  • Rifampin
  • Rofecoxib
  • Spirapril
  • Sulindac
  • Suprofen
  • Temocapril
  • Tenidap
  • Tenoxicam
  • Tiaprofenic Acid
  • Ticrynafen
  • Tolmetin
  • Topiramate
  • Torsemide
  • Trandolapril
  • Trichlormethiazide
  • Trimethoprim
  • Valdecoxib
  • Xipamide
  • Zofenopril
  • Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of enalapril and hydrochlorothiazide. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angioedema, history of—May increase the risk of this condition occurring again .
  • Anuria (not able to pass urine)—enalapril and hydrochlorothiazide should not be used in patients with this condition .
  • Asthma, bronchial—enalapril and hydrochlorothiazide may cause sensitivity reactions .
  • Congestive heart failure (severe) or
  • Dehydration or
  • Diarrhea or
  • Heart or blood vessel disease or
  • Hyponatremia (low sodium in the blood) or
  • Kidney disease—These conditions may cause the blood pressure to fall too low with enalapril and hydrochlorothiazide .
  • Diabetes or
  • Gout or
  • Hypercholesterolemia (high cholesterol in the blood) or
  • Hyperuricemia (high uric acid in the blood) or
  • Liver disease or
  • Systemic lupus erythematosus (SLE)—These conditions may be made worse .

Proper Use of enalapril and hydrochlorothiazide

In addition to the use of enalapril and hydrochlorothiazide, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that enalapril and hydrochlorothiazide will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Dosing

The dose of enalapril and hydrochlorothiazide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of enalapril and hydrochlorothiazide. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For high blood pressure:
      • Adults—1 or 2 tablets taken as a single dose or two times a day.
      • Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of enalapril and hydrochlorothiazide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using enalapril and hydrochlorothiazide

It is very important that your doctor check your progress at regular visits to make sure enalapril and hydrochlorothiazide is working properly and to check for unwanted effects. Blood tests may be needed to check for unwanted effects .

Stop using enalapril and hydrochlorothiazide and call your doctor right away if you have swelling of the face, arms, legs, eyes, lips, or tongue, or problems with swallowing or breathing. These are symptoms of a condition called angioedema .

You may experience lightheadedness during the first few days with enalapril and hydrochlorothiazide. If this becomes severe and you faint, stop using enalapril and hydrochlorothiazide and talk to your doctor right away .

enalapril and hydrochlorothiazide may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor .

Tell your doctor immediately if you have any signs of infection such as chills, sore throat, or fever. These may be symptoms of an immune system condition called neutropenia .

Using enalapril and hydrochlorothiazide while you are pregnant can harm your unborn baby. If you think you have become pregnant while using enalapril and hydrochlorothiazide, tell your doctor right away .

Check with your doctor right away if you have symptoms of jaundice (yellow skin or eyes) because these may be signs of a serious liver condition .

enalapril and hydrochlorothiazide may increase the amount of potassium in your blood. Do not use salt substitutes containing potassium without first checking with your doctor .

Make sure any doctor or dentist who treats you knows that you are using enalapril and hydrochlorothiazide. You may need to stop using enalapril and hydrochlorothiazide several days before having surgery or medical tests .

If your symptoms do not improve within a few days or if they become worse, check with your doctor .

enalapril and hydrochlorothiazide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Blurred vision
  • chest pain or discomfort
  • chills
  • cold sweats
  • coma
  • confusion
  • decreased urine output
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • drowsiness
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • increased thirst
  • irritability
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in hands, feet, or lips
  • rapid breathing
  • seizures
  • shortness of breath
  • sunken eyes
  • sweating
  • swelling of face, ankles, or hands
  • thirst
  • unusual tiredness or weakness
  • weak pulse
  • wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Cough
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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