Ecallantide

Ecallantide is used for:

Treating sudden attacks of HAE.

Ecallantide is a human plasma kallikrein inhibitor. It works by blocking substances that cause swelling, inflammation, and pain associated with HAE.

Do NOT use Ecallantide if:

• you are allergic to any ingredient in Ecallantide or have had a severe allergic reaction to Ecallantide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ecallantide :

Some medical conditions may interact with Ecallantide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Ecallantide . However, no specific interactions with Ecallantide are known at this time.

Ask your health care provider if Ecallantide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ecallantide :

Use Ecallantide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Ecallantide comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Ecallantide refilled.
• Ecallantide is usually given as an injection at your doctor's office, hospital, or clinic.
• Do not use Ecallantide if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• If you miss a dose of Ecallantide , contact your doctor right away.

Ask your health care provider any questions you may have about how to use Ecallantide .

Important safety information:

• Use Ecallantide with caution in the ELDERLY; they may be more sensitive to its effects.
• Ecallantide should be used with extreme caution in CHILDREN younger than 15 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is not known if Ecallantide can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ecallantide while you are pregnant. It is not known if Ecallantide is found in breast milk. If you are or will be breast-feeding while you use Ecallantide , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Ecallantide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Ecallantide is usually handled and stored by a health care provider. If you are using Ecallantide at home, store Ecallantide as directed by your pharmacist or health care provider. Keep Ecallantide out of the reach of children and away from pets.

General information:

• If you have any questions about Ecallantide , please talk with your doctor, pharmacist, or other health care provider.
• Ecallantide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Ecallantide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.