Commonly used brand name(s):
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antineoplastic Agent
Pharmacologic Class: Tyrosine Kinase Inhibitor
Dasatinib is used to prevent and stop the growth of cancer cells in patients with chronic myeloid leukemia (CML). CML is a disease in which your body makes too many abnormal white blood cells, which can cause you to become sick more often and to feel weak or tired. Dasatinib helps your body stop making these abnormal white blood cells.
Dasatinib is also used to treat other conditions such as Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
Before you begin treatment with dasatinib, you and your doctor should talk about the good dasatinib will do as well as the possible risks of using it. dasatinib is usually used in patients who have already taken other cancer medicines (e.g., imatinib [Gleevec®]).
dasatinib is available only with your doctor's prescription.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dasatinib, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to dasatinib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of dasatinib in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dasatinib in the elderly. However, some elderly patients may be more sensitive than younger adults to the effects of dasatinib.
|All Trimesters||D||Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Using dasatinib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using dasatinib with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using dasatinib with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use dasatinib, or give you special instructions about the use of food, alcohol, or tobacco.
The presence of other medical problems may affect the use of dasatinib. Make sure you tell your doctor if you have any other medical problems, especially:
dasatinib comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.
Keep using dasatinib for as long as your doctor has told you to. Do not change your dose or stop taking dasatinib without first talking with your doctor.
You may take dasatinib with or without food.
Swallow the tablet whole. Do not crush, break, or chew it.
Grapefruits and grapefruit juice may increase the effects of dasatinib by increasing the amount of dasatinib in your body. You should not eat grapefruit or drink grapefruit juice while you are taking dasatinib.
If you are using antacids (e.g., aluminum hydroxide, magnesium hydroxide, Maalox®, Tums®, or Rolaids®), take it at least 2 hours before or 2 hours after you take dasatinib.
The dose of dasatinib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of dasatinib. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of dasatinib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
It is very important that your doctor check your progress at regular visits to make sure that dasatinib is working properly. Blood tests will be needed to check for unwanted effects.
Using dasatinib while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.
Use an effective form of birth control to keep from getting pregnant. Some forms of birth control include condoms, diaphragms, or birth control pills. Men using dasatinib should use a condom to avoid pregnancy in their partner.
Dasatinib can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Your doctor will need to check your blood at regular visits while you are using dasatinib. Be sure to keep all appointments.
Dasatinib may cause fluid retention. Check with your doctor right away if you have a decrease in amount of urine; noisy or rattling breathing; shortness of breath; swelling of the fingers, hands, feet, or lower legs; troubled breathing at rest; or weight gain.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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