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Drugs reference index «Botulinum Toxin Type A»

Botulinum Toxin Type A


Generic Name: onabotulinumtoxinABrand Name: Botox Cosmetic

onabotulinumtoxinA may spread from the injection site to other areas of the body causing symptoms of a serious condition called botulism. These symptoms may occur hours to weeks after you receive onabotulinumtoxinA . Symptoms may include loss of strength; muscle weakness; double or blurred vision; drooping eyelids; hoarseness; loss of voice; loss of bladder control; or trouble speaking, breathing, or swallowing. The risk may be greater in children being treated for spasticity (muscle spasms), but these symptoms may also occur in adults. onabotulinumtoxinA is not approved for use in children. Contact your doctor immediately if these symptoms occur.

Severe and sometimes fatal breathing or swallowing problems have been reported. The risk may be greater in patients who already have breathing or swallowing problems. Tell your doctor if you have or are at risk of developing breathing or swallowing problems.

onabotulinumtoxinA is used for:

Temporarily improving the appearance of moderate to severe lines between the eyebrows in patients 65 years old or younger. It may also be used for other conditions as determined by your doctor.

onabotulinumtoxinA is a neurotoxin. It works by blocking nerve impulses to the muscles or sweat glands, temporarily paralyzing the muscle or gland.

Do NOT use onabotulinumtoxinA if:

  • you are allergic to any ingredient in onabotulinumtoxinA or another botulinum product
  • you have an infection at the injection site
  • you are pregnant

Contact your doctor or health care provider right away if any of these apply to you.

Before using onabotulinumtoxinA :

Some medical conditions may interact with onabotulinumtoxinA . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have nerve problems or disease (eg, amyotrophic lateral sclerosis, motor neuropathy), muscle problems or disease (eg, Lambert-Eaton syndrome, myasthenia gravis), bleeding disorders, seizures, or severe weakness or wasting of the muscles at the injection site (eg, trouble raising your eyebrows, drooping eyelids)
  • if you have a history of heart problems (eg, irregular heartbeat, recent heart attack); swallowing or breathing problems (eg, asthma); or eye problems (eg, glaucoma)
  • if you have a skin infection; or inflammation, scarring, or other skin disorders at the injection site
  • if you plan to have surgery, especially surgery on your face, or if you have received onabotulinumtoxinA or any other botulinum toxin in the past 4 months

Some MEDICINES MAY INTERACT with onabotulinumtoxinA . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aminoglycosides (eg, gentamicin), anticholinesterase medicines (eg, neostigmine), lincosamides (eg, clindamycin), magnesium, neuromuscular blockers (eg, atracurium), polymyxin, or quinidine because the risk of toxic effects may be increased
  • Anticoagulants (eg, warfarin) because the risk of bleeding at the injection site may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if onabotulinumtoxinA may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use onabotulinumtoxinA :

Use onabotulinumtoxinA as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • onabotulinumtoxinA comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get onabotulinumtoxinA refilled.
  • onabotulinumtoxinA is usually given as an injection at your doctor's office, hospital, or clinic.
  • If you miss a dose of onabotulinumtoxinA , contact your doctor right away.

Ask your health care provider any questions you may have about how to use onabotulinumtoxinA .

Important safety information:

  • onabotulinumtoxinA may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use onabotulinumtoxinA with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT take more than the recommended dose or use onabotulinumtoxinA more often than every 3 months without checking with your doctor.
  • Do not switch brands of onabotulinumtoxinA . Contact your doctor if you have any questions.
  • onabotulinumtoxinA contains albumin, which comes from human blood. There is a very rare risk of getting a viral disease or a central nervous system disease called Creutzfeldt-Jakob disease from products with albumin. No cases of these problems have been found in patients who have used onabotulinumtoxinA .
  • onabotulinumtoxinA should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use onabotulinumtoxinA if you are pregnant. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using onabotulinumtoxinA while you are pregnant. It is not known if onabotulinumtoxinA is found in breast milk. If you are or will be breast-feeding while you use onabotulinumtoxinA , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of onabotulinumtoxinA :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; back pain; dizziness; drowsiness; dry mouth; dry or irritated eyes; facial pain; flu-like symptoms; headache; inability to focus eyes; increased cough; indigestion; nausea; neck pain; pain, redness, swelling, or tenderness at the injection site; runny nose; sensitivity to light; stiff or weak muscles at or near the injection site; sweating.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bleeding at the injection site; chest pain; difficulty swallowing or breathing; double or blurred vision, or other vision changes; drooping of the upper eyelid; eyelid swelling; fainting; fever, chills, or persistent sore throat; irregular heartbeat; loss of bladder control; loss of strength; paralysis; seizures; severe or persistent muscle weakness or dizziness; shortness or breath; speech changes or problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms of overdose may include paralysis; severe muscle weakness; trouble swallowing; weak or shallow breathing.

Proper storage of onabotulinumtoxinA :

onabotulinumtoxinA is usually handled and stored by a health care provider. If you are using onabotulinumtoxinA at home, store onabotulinumtoxinA as directed by your pharmacist or health care provider. Keep onabotulinumtoxinA out of the reach of children and away from pets.

General information:

  • If you have any questions about onabotulinumtoxinA , please talk with your doctor, pharmacist, or other health care provider.
  • onabotulinumtoxinA is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about onabotulinumtoxinA . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Botulinum Toxin Type A Professional Patient Advice (Wolters Kluwer)
  • Botox Prescribing Information (FDA)
  • Botox Consumer Overview
  • Dysport Prescribing Information (FDA)
  • Dysport Advanced Consumer (Micromedex) - Includes Dosage Information
  • Dysport Consumer Overview
  • botulinum toxin type a Intramuscular Advanced Consumer (Micromedex) - Includes Dosage Information

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