Trade Names:Cortisporin- Ointment 400 units/g bacitracin zinc, 3.5 mg/g neomycin, 5,000 units/g polymyxin B, 1% hydrocortisone
Sandoz Cortimyxin Ophthalmic Ointment (Canada)Inhibits protein synthesis by binding to ribosomal RNA, causing bacterial genetic code misreading.
Polymyxin BInteracts with phospholipid components of bacterial cell membrane, increasing cell wall permeability.
BacitracinInterferes with bacterial cell wall synthesis by inhibiting regeneration of phospholipid receptors involved with paptidoglycan synthesis.
HydrocortisoneSuppresses inflammatory response.
Treatment of corticosteroid-responsive dermatoses with secondary infection.
Use in the eyes or external ear canal (if the eardrum is perforated); tuberculosis; fungal or viral (eg, varicella zoster) lesions of the skin; hypersensitivity to any of components of product.
Topical Apply thin film to affected area 2 to 4 times daily, not to exceed 7 days.
Store at controlled room temperature (59° to 86°F). Keep tube tightly closed.
None well documented.
None well documented.
Acneiform eruption, allergic contact dermatitis, burning, dryness, folliculitis, hypertrichosis, hypopigmentation, itching, maceration of the skin, miliaria, perioral dermatitis, secondary infection, skin atrophy, skin sensitization, striae.
Ototoxicity.
Nephrotoxicity.
Allergic sensitivity.
Category C .
Hydrocortisone is excreted in breast milk following oral administration.
Safety and efficacy in children not established.
Prolonged use may result in bacterial or fungal overgrowth of nonsusceptible microorganisms.
Signs and symptoms of exogenous hyperadrenocorticism can occur with use of topical corticosteroids, especially if occlusive dressings are used.
Bacterial resistance to components of the product may develop.
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