Generic name: ZileutonBrand names: Zyflo
Zyflo tablets prevent and relieve the symptoms of chronic asthma. The drug works by relaxing the muscles in the walls of your airways, allowing them to open wider, and by reducing inflammation, swelling, and mucus secretion in the lungs.
Zyflo has been known to cause liver damage. Be sure to see your doctor every few months for liver function tests.
Zyflo should be taken 4 times a day. Although you can take it with or without meals, it may be easier to remember if you take it with meals and at bedtime. Take Zyflo exactly as prescribed, even when symptoms subside.
While taking Zyflo, you should continue taking all other asthma medications your doctor has prescribed, unless directed otherwise. Do not decrease the dose or stop taking any of these drugs.
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyflo.
If you have liver disease, you should not take Zyflo. You should also avoid Zyflo if you have ever had an allergic reaction to it or its ingredients.
Zyflo will not help an acute asthma attack in which immediate opening of the airways is needed.
If you find that you have to use your other asthma medications—such as an inhaler—more often, report this to your doctor.
Because Zyflo can affect the liver, make sure your doctor is aware of any problems you've had in the past. Warn the doctor, too, if you're a heavy drinker. Your liver function will be tested before you start Zyflo, and regularly thereafter. Be sure to go in for these tests. If they reveal liver damage, you'll have to stop taking Zyflo. Also be sure to tell your doctor immediately if you develop any symptoms of liver disease. These include pain in the upper right abdomen, nausea, fatigue, lethargy, itching, general discomfort, and jaundice (yellowing of the skin and eyes).
If Zyflo is taken with certain other drugs, the effects of either could be increased, decreased, or altered. You should check with your doctor before stopping or starting any prescription or nonprescription medicine. This is especially important with the following:AstemizoleBeta blockers (a type of heart and blood pressure medication)Calcium channel blockers (another type of heart and blood pressure medication)CisaprideCyclosporinTerfenadineTheophyllineWarfarin
While you are taking Zyflo, your theophylline dosage may need to be lowered, and your theophylline levels will have to be carefully watched. Dosages of propanolol may also need reduction, and warfarin dosages may need adjustment as well.
The effects of Zyflo in pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, ask your doctor whether you should continue taking Zyflo. It is not certain that the drug appears in breast milk, but taking Zyflo while nursing is not recommended. Discuss with your doctor whether it's best to stop taking the drug or to give up breastfeeding.
The recommended dosage is one 600-milligram tablet 4 times a day.
The safety and effectiveness of Zyflo in children under 12 years of age have not been established.
Because Zyflo is a relatively new drug, little is known about overdosage. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical treatment immediately.