Generic name: Selegiline hydrochlorideBrand names: Zelapar
Zelapar is used to help manage the symptoms of Parkinson's disease when treatment with levodopa/carbidopa alone is not working.
Zelapar should not be taken with tricyclic antidepressants or non-selective MAO inhibitors (such as Nardil or Parnate), or selective MAO-B inhibitors. The interaction between these drugs may cause sweating, mental changes or strange behavior, muscle stiffness, loss of consciousness, or death.
Zelapar should be taken in the morning before breakfast and without any liquids.
Do not try to push Zelapar through the back foil of the container; instead, peel the back of the Zelapar wrapper off to remove the medication.
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zelapar.
Do not take Zelapar if you are allergic to selegiline or any of the drug's other ingredients. Also, do not take Zelapar if you are taking the pain killer meperidine.
While being treated with Zelapar, avoid pregnancy, breastfeeding, and the products listed under "Possible food and drug interactions when taking Zelapar."
Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zelapar. Also, talk to your doctor about your complete medical history before beginning Parkinson's disease therapy.
If Zelapar is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zelapar with the following:
DextromethorphanMeperidineMonoamine oxidase inhibitors (MAOIs)Selective serotonin reuptake inhibitors (SSRIs)Tricyclic antidepressants
The effects of Zelapar during pregnancy and breastfeeding are unknown. Talk with your doctor before taking Zelapar if you are pregnant, plan to become pregnant, or are breastfeeding.
The usual dose of Zelapar is 1.25 milligrams (mg) once per day for a total of 6 weeks. After 6 weeks, the dosage of Zelapar may be increased to 2.5 mg per day.
Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.