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Drugs reference index «Z-Tuss 2»

Z-Tuss 2

Generic Name: chlorpheniramine, guaifenesin, hydrocodone, pseudoephedrine (KLOR fen IR a meen, gwye FEN e sin, HYE droe KOE done, SOO doe ee FED rin)Brand Names: Z-Tuss 2

What is chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Guaifenesin is an expectorant. It helps loosen mucus congestion in your chest and throat, making it easier to cough out through your mouth.

Hydrocodone is a narcotic cough suppressant similar to codeine. Hydrocodone affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine is used to treat sinus congestion, runny nose, sneezing, itching, watery eyes, cough, and chest congestion caused by allergies, upper respiratory infections, or the common cold.

This medication will not treat a cough that is caused by smoking, asthma, or emphysema.

Chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?Do not use this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cough and cold medicine before the MAO inhibitor has cleared from your body. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children. Chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine should not be given to a child younger than 6 years old. Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant.What should I discuss with my healthcare provider before taking chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before taking chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine, tell your doctor if you are allergic to any drugs, or if you have:

  • heart disease or high blood pressure;

  • asthma, COPD, sleep apnea, or other breathing disorders;

  • diabetes;

  • glaucoma;

  • a thyroid disorder;

  • epilepsy or other seizure disorder;

  • kidney or liver disease;

  • enlarged prostate or urination problems;

  • a stomach or intestinal disorder;

  • a history of head injury or brain tumor;

  • Addison's disease or other adrenal gland disorders; or

  • a history of drug or alcohol addiction.

FDA pregnancy category C. Hydrocodone may be harmful to an unborn baby, and could cause addiction or withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Hydrocodone should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription. Older adults may be more likely to have side effects from this medication.How should I take chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Cough or cold medicine is usually taken for only a short time until your symptoms clear up.

Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children. Chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine should not be given to a child younger than 6 years old. Take this medication with food or milk if it upsets your stomach.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Drink plenty of water or other fluids to help loosen congestion and prevent dry mouth or throat. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store this medicine at room temperature, away from heat, light, and moisture. Keep track of how much of this medicine has been used from each new bottle. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of hydrocodone can be fatal.

Overdose symptoms may include fast or uneven heart rate, extreme drowsiness, feeling restless or hyperactive, confusion, hallucinations, warmth or redness in your face, cold or clammy skin, blue-colored lips or fingernails, weak or shallow breathing, fainting, or seizure (convulsions).

What should I avoid while taking chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not drink alcohol while you are taking this medication. Alcohol can increase some of the side effects of chlorpheniramine, guaifenesin, or hydrocodone. Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant.

Chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:
  • severe dizziness, fainting, anxiety, restless feeling, nervousness, or tremor;

  • fast, pounding, or uneven heartbeats;

  • slow heartbeat, weak pulse, shallow breathing;

  • confusion, hallucinations, unusual thoughts or behavior;

  • ringing in your ears;

  • painful or difficult urination;

  • pale skin, easy bruising or bleeding, unusual weakness; or

  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

Less serious side effects may include:

  • dizziness, drowsiness, headache;

  • blurred vision;

  • dry mouth, nose, or throat;

  • nausea, stomach pain, constipation; or

  • restless or excitability (especially in children).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?Before taking this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine, guaifenesin, or hydrocodone.

Before taking this medication, tell your doctor if you are using any of the following drugs:

  • sibutramine (Meridia);

  • guanethidine (Ismelin);

  • memantine (Namenda);

  • methyldopa (Aldomet);

  • reserpine;

  • an antidepressant such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others; or

  • a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others.

This list is not complete and there may be other drugs that can interact with chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 4/12/2009 4:46:21 PM.

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