Generic Name: pazopanib (paz OH pa nib)Brand Names: Votrient
Pazopanib is a cancer medication that interferes with the growth of cancer cells and slows their spread in the body.
Pazopanib is used to treat advanced renal cell carcinoma (kidney cancer).
Pazopanib may also be used for other purposes not listed in this medication guide.
Before you take pazopanib, tell your doctor if you have liver disease, heart disease, high blood pressure, underactive thyroid, an ulcer or other stomach disorder, or a history of "Long QT syndrome," blood clot, or bleeding (stomach, intestinal, or brain).There are many other medicines that can interact with pazopanib. Tell your doctor about all the prescription and over-the-counter medications you use. You will need regular medical tests to be sure this medication is not causing harmful effects. Do not miss any follow-up visits to your doctor. If you need to have any type of surgery, tell the surgeon ahead of time that you are using pazopanib. Stop using pazopanib and call your doctor at once if you have a serious side effect such as bloody or tarry stools, coughing up blood, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes), sudden numbness or weakness, problems with speech or balance, chest pain, or vision and hearing problems.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:
high blood pressure;
a personal or family history of "Long QT syndrome";
a history of blood clot;
an ulcer or other stomach disorder;
a head injury or bleeding in your brain within the past 6 months; or
stomach or intestinal bleeding within the past 6 months.
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.Take pazopanib on an empty stomach, at least 1 hour before or 2 hours after a meal.
Pazopanib is usually taken once per day. Your doctor may occasionally change your dose to make sure you get the best results from this medication.Do not crush a pazopanib tablet. Swallow the pill whole. Crushing the pill may cause your body to absorb too much of the drug at one time. To be sure this medication is not causing harmful effects, your blood and urine may need to be tested on a regular basis. Your heart rate may also need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Do not miss any follow-up visits to your doctor. If you need to have any type of surgery, tell the surgeon ahead of time that you are using pazopanib. You may need to stop using the medicine for a short time. Store pazopanib at room temperature away from moisture and heat.
See also: Votrient dosage in more detail
Take the missed dose as soon as you remember. If your next dose is less than 12 hours away, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include extreme tiredness or high blood pressure (severe headache, hearing or vision problems, anxiety, chest pain, shortness of breath, uneven heartbeats).
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
slow healing of a wound or surgical incision;
dizziness, fainting, fast or pounding heartbeat;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
sudden numbness or weakness (especially on one side of the body), sudden headache, confusion, problems with vision, speech, or balance;
chest pain or heavy feeling, pain spreading to the arm or shoulder; or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, shortness of breath, uneven heartbeats, seizure).
Less serious side effects may include:
mild nausea or vomiting, diarrhea;
changes in hair color;
tired feeling; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Many drugs can interact with pazopanib. Below is just a partial list. Tell your doctor if you are using:
an antibiotic or antifungal medication;
an antidepressant or medicine to treat a psychiatric disorder;
asthma or allergy medication;
diabetes medication you take by mouth;
drugs to treat erectile dysfunction;
heart or blood pressure medications, heart rhythm medication;
HIV or AIDS medications;
medicines used to prevent organ transplant rejection;
medicine to treat or prevent nausea and vomiting;
migraine headache medicines, including ergot medicines or "triptans";
other cancer medications;
sedatives or narcotic pain medication;
seizure medication; or