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Drugs reference index «Vantas»



Generic Name: histrelin acetate (Subcutaneous route)

Commonly used brand name(s):

In the U.S.

  • Supprelin LA
  • Vantas

Available Dosage Forms:

  • Kit
  • Implant

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Histrelin

Uses For Vantas

Histrelin is a type of medicine called a gonadotropin-releasing hormone (GnRH) antagonist. Histrelin (Vantas™) lowers the male hormone testosterone in your blood. Testosterone makes most prostate cancers grow. The histrelin implant is a drug-delivery system that contains the medicine histrelin and is placed under the skin. After it is placed under the skin it releases histrelin to the body continuously for 12 months. Histrelin is not a cure for prostate cancer but it may help to relieve the symptoms of prostate cancer.

Histrelin (Supprelin® LA) is also used to treat central precocious puberty (CPP), a condition in which puberty begins at an unusually early age (before 8 years of age in girls and before 9 years of age in boys). It works by reducing the amount of hormones in the blood to delay early puberty. Signs of early puberty may include breast enlargement, pubic and underarm hair, and rapid height increase .

This medicine is available only with your doctor's prescription.

Before Using Vantas

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Histrelin (Vantas™) is not for use in children.

Appropriate studies have not been performed on the relationship of age to the effects of histrelin (Supprelin® LA) in children below 2 years of age. Safety and efficacy have not been established .


This medicine has been tested and has not been shown to cause different side effects or other problems in older people than it does in younger adults.


Pregnancy CategoryExplanation
All TrimestersXStudies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Nerve problems caused by bone lesions in spine or
  • Problems in passing urine—Conditions may get worse for a short time after histrelin treatment is started.

Proper Use of histrelin acetate

This section provides information on the proper use of a number of products that contain histrelin acetate. It may not be specific to Vantas. Please read with care.

Histrelin comes with patient instructions. Read these instructions carefully.

This medicine is an implant that is surgically placed under the skin of the upper arm. Your doctor will treat the arm with numbing medicine and then cut a small incision to insert the implant with a special tool. The incision will be closed either with stitches or surgical strips. A pressure bandage will be placed over the arm and should be left on for 24 hours .

Do not remove any surgical strips, rather allow them to fall off on their own after several days. If the incision has been stitched, your doctor will remove the stitches, or they will dissolve after several days.

After the implant is put in place, you or your child should keep the arm clean and dry, and should not swim or bathe for 24 hours. You or your child should avoid any heavy lifting or strenuous exercise for the first 7 days after the implant is put into the arm.

The implant will be left in place for one year and then removed. If needed, your doctor will then insert a new implant to continue treatment for another year.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Precautions While Using Vantas

It is very important that your doctor check your progress at regular visits to ensure histrelin implant is in place and functioning in your body.

This medicine may cause loss in bone mineral density with extended treatment. Loss in bone mineral density can lead to the thinning of bones (osteoporosis). If you have any questions about this, ask your doctor.

You should not receive this medicine if you are pregnant or may become pregnant. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away .

Histrelin (Supprelin® LA) can cause a brief increase in some hormones, and during this time you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. If your child's symptoms do not improve within 4 weeks, or if they get worse, call your doctor. .

Vantas Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • Bloody urine
  • decreased frequency or amount of urine
  • increased blood pressure
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • nausea
  • swelling of face, fingers, or lower legs
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Decrease in testicle size
  • feeling of warmth
  • local infection, irritation, redness, or swelling of skin
  • redness of the face, neck, arms and occasionally, upper chest
  • sudden sweating
Less common
  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • flushing, redness of skin
  • headache
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • sleeplessness
  • swelling of the breast or breast soreness in both females and males
  • trouble sleeping
  • unable to sleep
  • unusually warm skin
  • Redness, feeling of heat
  • swelling
Reported during clinical trials
  • Abnormal ejaculation
  • appetite increased
  • bone pain
  • breast pain
  • breast tenderness
  • burning while urinating
  • cholesterol in the blood
  • collection of blood under the skin
  • confusion
  • dark urine
  • deep dark purple bruise
  • difficult or painful urination
  • difficulty in moving
  • discouragement
  • dizziness
  • dry mouth
  • dullness
  • extra heartbeat
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling cold
  • feeling of sluggishness
  • feeling sad or empty
  • fever with or without chills
  • food craving
  • general feeling of discomfort or illness
  • incoherent speech
  • increased need to urinate
  • irritability
  • itching or pain of the genital area
  • itching, pain, redness, or swelling
  • joint pain
  • large, flat, blue or purplish patches in the skin
  • light-colored stools
  • loss if interest of pleasure
  • metallic taste
  • muscle aching or cramping
  • muscle pain or stiffness
  • muscle twitching
  • muscle weakness
  • neck pain
  • night sweats
  • noisy, rattling breathing
  • pain
  • pain in limb
  • pain or burning while urinating
  • pale skin shakiness in legs, arms, hands, or feet
  • shortness of breath
  • stent occlusion
  • stomach pain
  • stomach soreness or discomfort
  • sweating increased
  • swollen joints
  • tightness in chest
  • tingling of hands and feet
  • trembling or shaking of hand or feet
  • trouble concentrating
  • trouble sleeping
  • unusual bleeding or busing
  • unusual drowsiness
  • unusual weight loss
  • wheezing
  • yellow eyes or skin

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  • Vantas Prescribing Information (FDA)
  • Vantas Consumer Overview
  • Vantas Implant MedFacts Consumer Leaflet (Wolters Kluwer)
  • Supprelin LA Implant MedFacts Consumer Leaflet (Wolters Kluwer)
  • Supprelin LA Prescribing Information (FDA)