Generic name: Trimethobenzamide hydrochlorideBrand names: Tigan
Tigan is prescribed to control nausea and vomiting.
Antiemetics (drugs that prevent or lessen nausea and vomiting) are not recommended for the treatment of simple vomiting in children. Use of Tigan in children should be limited to prolonged vomiting caused by a known disease. Tigan is thought to have an aggravating effect on Reye's syndrome (a potentially fatal childhood disease of the brain that sometimes strikes after a viral infection such as chickenpox). In addition, some of Tigan's side effects can actually be confused with the symptoms of Reye's syndrome.
Take Tigan exactly as prescribed.
If you are using the suppository form of Tigan and find it is too soft to insert, you can firm it up by chilling it in the refrigerator for about 30 minutes or running cold water over it before removing the wrapper.
To insert a suppository, first remove the wrapper and moisten the suppository with cold water. Then lie down on your side and use a finger to push the suppository well up into the rectum.
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Tigan.
If you are sensitive to or have ever had an allergic reaction to Tigan do not take Tigan. Do not use the suppositories if you are allergic to benzocaine or other local anesthetics. Make sure your doctor is aware of any drug reactions you have experienced.
Do not use suppositories in premature or newborn infants.
Tigan may cause you to become drowsy or less alert. Do not drive or operate dangerous machinery or participate in any hazardous activity that requires full mental alertness until you know how you respond to Tigan.
During illnesses such as high fever, inflammation of the brain, inflammation of the digestive tract, or dehydration, Tigan should be used with caution, especially in children, older adults, and anyone in a run-down condition. Under these circumstances, the drug is more likely to cause severe reactions such as convulsions and coma.
Severe vomiting should not be treated with Tigan alone. Your doctor should emphasize restoration of body fluids, the relief of fever, and the relief of the disease causing the vomiting. However, the overconsumption of fluids may result in cerebral edema (excessive accumulation of fluid in the brain).
The antinausea effects of Tigan may make it difficult to diagnose such conditions as appendicitis and may mask signs of drug poisoning due to overdosage of other drugs.
The use of alcohol in combination with Tigan may produce an unfavorable reaction.
Caution should be exercised when taking Tigan in combination with central nervous system drugs such as phenothiazines (tranquilizers and antiemetics), barbiturates such as phenobarbital, and drugs derived from belladonna, such as Donnatal, if you are dehydrated or have a severe disease with fever, inflammation of the stomach, intestines, or brain.
The effects of Tigan during pregnancy or breastfeeding have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. If you are breastfeeding your baby, consult your doctor before taking Tigan.
Dosage will be adjusted by your doctor according to your illness, the severity of your symptoms, and how well you do on the drug.
The usual dosage is one 300-milligram capsule taken 3 or 4 times per day, as determined by your doctor.
The recommended dosage is 1 suppository (200 milligrams) inserted into the rectum 3 or 4 times per day, as determined by your doctor.
The usual dosage for children weighing 30 to 90 pounds is one or two 100-milligram capsules taken 3 or 4 times per day, as determined by the doctor.
The usual dosage for children weighing under 30 pounds is half a suppository (100 milligrams), inserted into the rectum 3 or 4 times a day, as determined by your doctor.
The usual dosage for children weighing 30 to 90 pounds is one-half to one 200-milligram suppository rectally 3 or 4 times a day, as determined by the doctor.
The usual dosage for children weighing under 30 pounds is 1 suppository (100 milligrams) rectally 3 or 4 times a day, as determined by the doctor.
The usual dosage for children weighing 30 to 90 pounds is 1 to 2 suppositories (100 milligrams to 200 milligrams) rectally 3 or 4 times a day, as determined by the doctor.
Although no specific information is available, any medication taken in excess can have serious consequences. If you suspect a Tigan overdose, seek medical attention immediately.