Generic Name: ticlopidine (oral) (tye KLOE pi deen)Brand Names: Ticlid
Ticlopidine keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.
Ticlopidine is used to prevent blood clots after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels.
Ticlopidine may also be used for other purposes not listed in this medication guide.
Before taking ticlopidine, tell your doctor if you have a bleeding or blood clotting disorder, a history of stroke, including TIA ("mini-stroke"), a stomach ulcer or ulcerative colitis, high cholesterol or triglycerides, liver disease, or kidney disease.
Because ticlopidine keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.If you need to have any type of surgery, tell the surgeon ahead of time that you are using ticlopidine. While you are taking ticlopidine, do not take aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin) without your doctor's advice. Taking ticlopidine with certain other drugs can increase your risk of bleeding. Before taking ticlopidine, tell your doctor about all other medications you use.
severe liver disease;
any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head injury); or
a blood cell disorder such as anemia (lack of red blood cells) or low levels of platelets (cells that help your blood clot).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take ticlopidine:
a bleeding or blood clotting disorder, such as hemophilia;
a history of stroke, including TIA ("mini-stroke");
a stomach ulcer or ulcerative colitis;
high cholesterol or triglycerides;
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.Take this medication with a full glass of water. Take ticlopidine with food.
Because ticlopidine keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.If you need to have any type of surgery, tell the surgeon ahead of time that you are using ticlopidine. Store ticlopidine at room temperature away from moisture and heat.
See also: Ticlopidine dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include cold feeling, unusual bleeding, trouble breathing, loss of balance or coordination, and seizure (convulsions).
Avoid sports or activities that could result in a bruising or bleeding injury. Use extra caution to avoid cuts when brushing your teeth or shaving.Avoid drinking alcohol while taking ticlopidine. Alcohol may increase your risk of bleeding in your stomach or intestines.
nosebleed or other bleeding that will not stop;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, problems with vision, speech, or balance; or
pale skin, easy bruising or bleeding, weakness, fever, and urinating more or less than usual;
signs of infection such as fever, chills, sore throat, flu symptoms, mouth sores; or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
upset stomach, nausea, or vomiting;
ringing in your ears;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Cerebral Thrombosis/Embolism:
250 mg orally twice a day.
heparin, dalteparin (Fragmin), or enoxaparin (Lovenox);
dipyridamole (Persantine); or
an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others.
Tell your doctor about all other medications you use, especially:
antacids or cimetidine (Tagamet, Tagamet HB);
digoxin (Lanoxin, Lanoxicaps);
theophylline (Elixophyllin, Theo-24, Uniphyl); or
This list is not complete and there may be other drugs that can interact with ticlopidine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.