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ticarcillin and clavulanate potassium

Generic Name: ticarcillin and clavulanate potassium (injection) (TYE kar SIL in KLAV ue la nate poe TAS ee um)Brand Names: Timentin

What is ticarcillin and clavulanate potassium?

Ticarcillin is an antibiotic in a group of drugs called penicillins. Ticarcillin fights bacteria in the body.

Clavulanate potassium is a form of clavulanic acid, which is similar to penicillin. Clavulanate potassium fights bacteria that is often resistant to penicillins and other antibiotics.

The combination of ticarcillin and clavulanate potassium is used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, and skin infections.

Ticarcillin and clavulanate potassium may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about ticarcillin and clavulanate potassium?Do not use this medication if you are allergic to clavulanate potassium, ticarcillin or to any other penicillin antibiotic, such as amoxicillin (Amoxil, Augmentin), ampicillin (Omnipen, Principen), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using ticarcillin and clavulanate potassium tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others, or if you have kidney disease, a bleeding or blood clotting disorder, low levels of potassium in your blood, a history of any type of allergy, or if you are on a salt-restricted diet.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ticarcillin and clavulanate potassium will not treat a viral infection such as the common cold or flu. Ticarcillin and clavulanate potassium can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ticarcillin and clavulanate potassium.What should I discuss with my healthcare provider before using ticarcillin and clavulanate potassium?Do not use this medication if you are allergic to clavulanate potassium, ticarcillin, or to any other penicillin antibiotic, such as:
  • amoxicillin (Amoxil, Augmentin);

  • ampicillin (Omnipen, Principen);

  • carbenicillin (Geocillin);

  • dicloxacillin (Dycill, Dynapen);

  • oxacillin (Bactocill); or

  • penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others).

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using ticarcillin and clavulanate potassium, tell your doctor if you are allergic to any drugs (especially cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others), or if you have:

  • kidney disease;

  • a bleeding or blood clotting disorder;

  • an electrolyte imbalance such as low levels of potassium in your blood;

  • a history of any type of allergy; or

  • if you are on a salt-restricted diet.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Ticarcillin and clavulanate potassium can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ticarcillin and clavulanate potassium. It is not known whether ticarcillin and clavulanate potassium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use ticarcillin and clavulanate potassium?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Ticarcillin and clavulanate potassium is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to use your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.

Ticarcillin and clavulanate potassium must be mixed with a liquid (diluent) before injecting it. Do not mix the medicine until you are ready to give yourself an injection.

Ticarcillin and clavulanate potassium is usually given for 10 to 14 days, depending on the infection being treated. Follow your doctor's instructions.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ticarcillin and clavulanate potassium will not treat a viral infection such as the common cold or flu.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using ticarcillin and clavulanate potassium.

Store unmixed ticarcillin and clavulanate potassium, and the liquid diluent, at cool room temperature.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include drowsiness, hyperactivity, or seizure (convulsions).

What should I avoid while using ticarcillin and clavulanate potassium?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Ticarcillin and clavulanate potassium side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • diarrhea that is watery or bloody;

  • blood in your urine, feeling an urgent need to urinate, painful or difficult urination;

  • easy bruising or bleeding, unusual weakness;

  • dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting;

  • fever, chills, body aches, flu symptoms;

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

  • chest pain; or

  • seizure (convulsions).

Less serious side effects may include:

  • mild diarrhea, gas, stomach pain;

  • nausea or vomiting;

  • joint or muscle pain;

  • headache;

  • skin rash or itching;

  • pain, swelling, or burning where the injection was given; or

  • vaginal yeast infection (itching or discharge).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ticarcillin and clavulanate potassium Dosing Information

Usual Adult Dose for Aspiration Pneumonia:

3.1 g IV every 4 to 6 hoursDuration: Therapy of documented anaerobic pleuropulmonary infections should be continued until after the infiltrate has cleared or a residual scar forms, sometimes requiring 2 to 4 months of therapy.

Usual Adult Dose for Bacteremia:

3.1 g IV every 4 hoursDuration: 14 days

Usual Adult Dose for Septicemia:

3.1 g IV every 4 hoursDuration: 14 days

Usual Adult Dose for Deep Neck Infection:

3.1 g IV every 4 to 6 hoursDuration: 3 or 4 weeks, depending on the nature and severity of the infection

Usual Adult Dose for Endometritis:

Moderate infection: 50 mg/kg (ticarcillin component) IV every 6 hoursSevere infection: 50 mg/kg (ticarcillin component) IV every 4 hoursDuration: Parenteral therapy should be continued for at least 24 hours after the patient has remained afebrile, pain free, and the leukocyte count has normalized. Doxycycline therapy for 14 days is recommended if concurrent chlamydial infection is present in late postpartum patients (breast-feeding should be discontinued).

Usual Adult Dose for Febrile Neutropenia:

3.1 g IV every 4 to 6 hoursDuration: Therapy should be continued for approximately 14 days, or until more specific therapy may be substituted for a proven infection, or until the patient has been afebrile for 24 hours after the absolute neutrophil count has been greater than 500 cells/mm3.

Usual Adult Dose for Intraabdominal Infection:

3.1 g IV every 4 to 6 hoursDuration: Therapy should be continued for 7 to 14 days depending on the nature and severity of the infection.

Usual Adult Dose for Peritonitis:

3.1 g IV every 4 to 6 hoursDuration: Therapy should be continued for 7 to 14 days depending on the nature and severity of the infection.

Usual Adult Dose for Joint Infection:

3.1 g IV every 4 to 6 hours Duration: Therapy should be continued for 3 or 4 weeks, depending on the nature and severity of the infection. Longer therapy, sometimes up to 6 weeks, may be necessary for prosthetic joint infections.

Usual Adult Dose for Osteomyelitis:

3.1 g IV every 4 hoursDuration: Therapy should be continued for 4 to 6 weeks. Chronic osteomyelitis may require additional oral antimicrobial therapy, possibly up to 6 months.

Usual Adult Dose for Pelvic Inflammatory Disease:

Moderate infection: 50 mg/kg (ticarcillin component) IV every 6 hoursSevere infection: 50 mg/kg (ticarcillin component) IV every 4 hoursDuration: Parenteral therapy should continue for 24 hours after clinical improvement is observed at which time oral therapy may be initiated and continued for a total of 14 days of treatment.If the patient is not pregnant, appropriate treatment for possible chlamydial infection should be initiated and any sexual partner(s) should be evaluated/treated.

Usual Adult Dose for Pneumonia:

3.1 g IV every 4 to 6 hoursDuration: 7 to 10 days if pneumococcus is suspected organism, up to 21 days if another microbe is suspected

Usual Adult Dose for Pyelonephritis:

3.1 g IV every 4 to 6 hoursDuration: 14 days

Usual Adult Dose for Skin or Soft Tissue Infection:

3.1 g IV every 4 to 6 hoursDuration: Therapy should be continued for up to 3 days after acute inflammation resolves, depending on the nature and severity of the infection. For more severe infections, such as diabetic soft tissue infections, up to 21 days of therapy may be required.

Usual Adult Dose for Urinary Tract Infection:

3.1 g IV every 4 to 6 hoursDuration: 14 days, depending on the nature and severity of the infection

Usual Pediatric Dose for Intraabdominal Infection:

Neonates:0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours3 months or older:59 kg or less:Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hoursSevere infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended60 kg or more:Mild to moderate infections: 3.1 g IV every 6 hoursSevere infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Joint Infection:

Neonates:0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours3 months or older:59 kg or less:Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hoursSevere infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended60 kg or more:Mild to moderate infections: 3.1 g IV every 6 hoursSevere infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Osteomyelitis:

Neonates:0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours3 months or older:59 kg or less:Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hoursSevere infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended60 kg or more:Mild to moderate infections: 3.1 g IV every 6 hoursSevere infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Pelvic Inflammatory Disease:

Neonates:0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours3 months or older:59 kg or less:Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hoursSevere infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended60 kg or more:Mild to moderate infections: 3.1 g IV every 6 hoursSevere infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Pneumonia:

Neonates:0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours3 months or older:59 kg or less:Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hoursSevere infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended60 kg or more:Mild to moderate infections: 3.1 g IV every 6 hoursSevere infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Skin or Soft Tissue Infection:

Neonates:0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours3 months or older:59 kg or less:Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hoursSevere infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended60 kg or more:Mild to moderate infections: 3.1 g IV every 6 hoursSevere infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Bacterial Infection:

Neonates:0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours3 months or older:59 kg or less:Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hoursSevere infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended60 kg or more:Mild to moderate infections: 3.1 g IV every 6 hoursSevere infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Urinary Tract Infection:

Neonates:0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours3 months or older:59 kg or less:Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hoursSevere infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended60 kg or more:Mild to moderate infections: 3.1 g IV every 6 hoursSevere infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Pneumonia with Cystic Fibrosis:

350 to 450 mg/kg/day (ticarcillin component) IV in divided doses every 6 hours

What other drugs will affect ticarcillin and clavulanate potassium?

There may be other drugs that can affect ticarcillin and clavulanate potassium. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about ticarcillin and clavulanate.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are using, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.06. Revision Date: 11/17/2009 9:37:34 PM.