Induces antibodies against toxins made by Corynebacterium diphtheriae and Clostridium tetani .
Achievement of active immunity against diphtheria and tetanus. Tetanus and diphtheria toxoids (Td) for adult use is preferred agent for immunizing most adults and children older than 7 yr of age.
Immediate hypersensitivity to product, thimerosal, or any product components; during immunosuppression, acute respiratory tract infection (except for emergency booster recall doses).
IM A total of 3 doses (0.5 mL each): 1 dose now followed by 1 dose 4 to 8 wk later and then 1 dose 6 to 12 mo after first dose.Booster DosesAdults
IM 0.5 mL at 10-yr intervals throughout life to maintain immunity.
None well documented.
None well documented.
Small amount of erythema, induration, pain, tenderness, heat, and edema surrounding injection site, persisting for a few days, is not unusual. Nodule may be palpable at injection site for a few weeks. Allow such nodules to recede spontaneously. Sterile abscess and subcutaneous atrophy occur rarely. Adverse reactions often associated with multiple prior booster doses may be manifested 2 to more than 12 h after administration by erythema, boggy edema, pruritus, lymphadenopathy, and induration surrounding point of injection. Pain and tenderness, if present, are usually not primary complaints.
Transient low-grade fever (temperatures over 38°C [100°F]) following Td administration are unusual; chills, malaise, generalized aches and pains, headaches, flushing, generalized urticaria or pruritus, tachycardia, anaphylaxis, hypotension, neurologic complications. People developing significant adverse reactions should not be given Td, even emergency doses, more frequently than every 10 yr.
Category C .
As with all IM injections, give drug with caution to people receiving anticoagulant therapy.
Like all inactivated vaccines, administration of Td to people receiving immunosuppressant drugs, including high-dose corticosteroids or radiation therapy, may result in insufficient response to immunization. They may remain susceptible despite immunization.
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