Generic Name: tenofovir (ten OF oh vir)Brand Names: Viread
Tenofovir is an antiviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.
Tenofovir is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Tenofovir is not a cure for HIV or AIDS. Tenofovir is also used to treat chronic hepatitis B.
Tenofovir may also be used for other purposes not listed in this medication guide.
If you have hepatitis B you may develop liver symptoms after you stop taking tenofovir, even months after stopping. Your doctor may want to check your liver function on a regular basis for several months after you stop using this medication. Do not miss any scheduled visits.
HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.
You should not take tenofovir if you are also taking Truvada (emtricitabine/tenofovir) or adefovir (Hepsera).If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before taking tenofovir, tell your doctor if you are allergic to any drugs, or if you have:
bone problems (such as osteopenia).
Your name may need to be listed on an antiviral pregnancy registry when you start using tenofovir. The purpose of this registry is to track the outcome of the pregnancy and delivery to evaluate whether tenofovir had any effect on the baby.You should not breast-feed while you are using tenofovir. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you may still pass the virus to the baby in your breast milk. Tenofovir should not be given to a child unless your doctor has told you otherwise.
Take tenofovir exactly as it was prescribed for you. Do not take the medication in larger or smaller amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.Take tenofovir with a full glass of water.
Tenofovir can be taken with or without food.It is important to take tenofovir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.
To be sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney and liver function may also need to be tested. Do not miss any scheduled visits to your doctor.
If you have hepatitis B you may develop liver symptoms after you stop taking this medication, even months after stopping. Your doctor may want to check your liver function at regular visits for several months after you stop using tenofovir. Do not miss any scheduled visits.Store tenofovir at room temperature away from moisture, heat, and direct light.
See also: Tenofovir dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
liver damage - nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
lactic acidosis - muscle pain or weakness, numb or cold feeling in your arms and legs, dizziness, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired;
kidney problems - increased thirst and urination, loss of appetite, weakness, constipation, urinating less than usual or not at all;
fever, chills, body aches, flu symptoms; or
any other signs of new infection.
Less serious side effects may include:
sleep problems (insomnia), strange dreams;
depression, headache, dizziness;
diarrhea, bloating, gas;
muscle or joint pain;
skin rash; or
changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and trunk).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for HIV Infection:
300 mg orally once a day
Usual Adult Dose for Chronic Hepatitis B:
300 mg orally once a dayThe optimum duration of treatment is not known.
Usual Adult Dose for Nonoccupational Exposure:
300 mg orally once a day plus efavirenz plus (emtricitabine or lamivudine)Prophylaxis should be initiated as soon as possible, within 72 hours of exposure.Duration: 28 days
Before taking tenofovir, tell your doctor if you are using any of the following drugs:
amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet);
pentamidine (Nebupent, Pentam);
antibiotics such as capreomycin (Capastat), rifampin (Rifadin, Rimactane, Rifater), vancomycin (Vancocin, Vancoled);
antiviral medicines such as acyclovir (Zovirax), cidofovir (Vistide), foscarnet (Foscavir), ganciclovir (Cytovene), valacyclovir (Valtrex), or valganciclovir (Valcyte);
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), indomethacin, naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others;
cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid); or
other HIV or AIDS medications such as atazanavir (Reyataz), didanosine (Videx), lopinavir and ritonavir (Kaletra).
This list is not complete and there are many other medicines that can interact with tenofovir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.