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Drugs reference index «Sorafenib»



Generic Name: Sorafenib (soe-RAF-e-nib)Brand Name: Nexavar

Sorafenib is used for:

Treating advanced kidney cancer. It is also used to treat certain patients with liver cancer. It may also be used for other conditions as determined by your doctor.

Sorafenib is a multikinase inhibitor. It works by decreasing tumor growth and replication.

Do NOT use Sorafenib if:

  • you are allergic to any ingredient in Sorafenib

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sorafenib :

Some medical conditions may interact with Sorafenib . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart problems (eg, disease of the blood vessels in the heart, recent heart attack), chest pain, high blood pressure, bleeding problems, active bleeding, or liver or kidney problems
  • if you are on dialysis or have had major surgery

Some MEDICINES MAY INTERACT with Sorafenib . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Doxorubicin or irinotecan because the risk of their side effects may be increased by Sorafenib
  • Warfarin because risk of bleeding may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sorafenib may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sorafenib :

Use Sorafenib as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Sorafenib . Talk to your pharmacist if you have questions about this information.
  • Take Sorafenib on an empty stomach at least 1 hour before or 2 hours after eating.
  • Swallow Sorafenib whole. Do not break, crush, or chew before swallowing.
  • Take Sorafenib with a full glass of water (8 oz/240 mL).
  • Continue to use Sorafenib even if you feel well. Do not miss any doses.
  • If you miss a dose of Sorafenib , skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sorafenib .

Important safety information:

  • Sorafenib may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Sorafenib may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Sorafenib .
  • Both men and women who are taking Sorafenib should use effective contraception (birth control) during treatment with Sorafenib and for at least 2 weeks after stopping treatment.
  • Lab tests, including blood pressure, may be performed while you use Sorafenib . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Sorafenib with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Sorafenib may cause harm to the fetus. Avoid becoming pregnant while taking Sorafenib and for at least 2 weeks after you stop taking it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sorafenib while you are pregnant. It is not known if Sorafenib is found in breast milk. Do not breast-feed while taking Sorafenib .

Possible side effects of Sorafenib :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dry skin; hair thinning or loss; headache; loss of appetite; mouth, bone, muscle, stomach, or joint pain; nausea; tiredness; vomiting; weakness; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; chest pain; confusion; coughing or vomiting blood; decreased sexual ability; decreased urination; depression; fainting; fever, chills, or sore throat; irregular heartbeat; mouth sores; numbness of an arm or leg; one-sided weakness; redness, pain, swelling, numbness, tingling, or blisters on the palms of hands or soles of feet; seizures; severe or persistent dizziness; severe stomach pain; shortness of breath; speech changes; sudden severe headache or vomiting; sudden weight gain; swelling of the ankles, hands, or feet; unusual bruising or bleeding; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include rash, redness, swelling, blistering, or itching of skin; severe or persistent diarrhea.

Proper storage of Sorafenib :

Store Sorafenib at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Sorafenib out of the reach of children and away from pets.

General information:

  • If you have any questions about Sorafenib , please talk with your doctor, pharmacist, or other health care provider.
  • Sorafenib is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Sorafenib . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Sorafenib Professional Patient Advice (Wolters Kluwer)
  • sorafenib Advanced Consumer (Micromedex) - Includes Dosage Information
  • Nexavar Prescribing Information (FDA)
  • Nexavar Consumer Overview

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