Trade Names:Kayexalate- Powder Finely powdered sodium polystyrene sulfonate. Sodium content approximately 100 mg (4.1 mEq)/g
Trade Names:SPS- Suspension 15 g/60 mL. Sodium content 1.5 g (65 mEq)Sodium Polystyrene Sulfonate (Canada)
Resin that exchanges sodium ions for potassium in large intestine.
Sodium polystyrene sulfonate is not absorbed from the GI tract.
Onset of action is hours to days.
Treatment of hyperkalemia.
PO or via NG tube 15 g 1 to 4 times/day. PR 30 to 50 g every 6 h has been given as daily enema.Children
PO Calculate children's dose by exchange ratio of 1 mEq potassium per gram of resin. (1 g/kg every 6 h has been recommended.)
Store at room temperature. Store repackaged product in refrigerator and use within 14 days. Do not store freshly prepared suspensions longer than 24 h. Do not heat, because this may alter exchange of properties of resin.
If hypokalemia occurs, likelihood of toxic effects of digoxin may be increased.Nonabsorbable cation donating antacids and laxatives (eg, aluminum carbonate, magnesium hydroxide)
Systemic alkalosis has occurred. Potassium exchange capability of sodium polystyrene sulfonate may be reduced. Intestinal obstruction due to concretions of aluminum hydroxide when used in combination has occurred.
None well documented.
Gastric irritation; anorexia; nausea; vomiting; constipation; fecal impaction.
Hypokalemia; hypocalcemia; sodium retention.
Category C .
Serious potassium deficiency can occur. Sodium polystyrene sulfonate is not totally selective for potassium and small amounts of magnesium and calcium can be lost. Use with caution in patients who cannot tolerate even small increase in sodium load (ie, severe CHF, severe hypertension, marked edema).
Treatment with this drug alone may be insufficient to rapidly correct severe hyperkalemia associated with states of rapid tissue breakdown (eg, burns, renal failure) or hyperkalemia so marked as to constitute medical emergency.
Nausea, vomiting, constipation (fecal impaction), hypokalemia, hypocalcemia, sodium retention.
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