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Drugs reference index «sevelamer»

sevelamer


sevelamer

Generic Name: sevelamer (se VEL a mer)Brand Names: Renagel, Renvela

What is sevelamer?

Sevelamer is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus.

Sevelamer is used to reduce blood levels of phosphorus in people with chronic kidney disease who are on dialysis.

Sevelamer may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about sevelamer?

You should not take this medication if you are allergic to sevelamer, or if you have a low blood level of phosphorus (hypophosphatemia), or a blockage in your intestines.

Before taking sevelamer, tell your doctor if you have trouble swallowing, severe constipation, a digestive disorder of your stomach or intestines, or if you have recently had stomach or intestinal surgery.

Avoid taking any other medicines within 1 hour before or 3 hours after you take sevelamer. Sevelamer can bind to other medications and make them less effective.

Before taking sevelamer, tell your doctor if you are taking ciprofloxacin (Cipro), a heart rhythm medication, or a seizure medication.

Do not take calcium or other mineral supplements without your doctor's advice. Use only the specific type of calcium or mineral supplement your doctor recommends.

What should I discuss with my healthcare provider before taking sevelamer?

You should not take this medication if you are allergic to sevelamer, or if you have:
  • a low blood level of phosphorus (hypophosphatemia); or

  • a blockage in your intestines.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • trouble swallowing;

  • severe constipation;

  • a digestive disorder of your stomach or intestines; or

  • if you have recently had stomach or intestinal surgery.

FDA pregnancy category C. It is not known whether sevelamer is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether sevelamer passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take sevelamer?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Take sevelamer with meals. Do not crush, chew, or break the sevelamer tablet. Swallow the pill whole. Sevelamer tablets expand when they are wet, and breaking or crushing the pill may make it harder to swallow.

Sevelamer powder must be dissolved in water before you take it. The 0.8-gram packet should be mixed with at least 1 ounce (2 tablespoons) of water. The 2.4-gram packet should be mixed with at least 2 ounces (4 tablespoons) of water.

Stir the powder in water until it is completely dissolved. Drink all of this mixture right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

To be sure this medication is helping your condition and not causing harmful effects, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Sevelamer may be only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must eat or avoid to help control your condition.

Store sevelamer tablets at room temperature away from moisture and heat.

See also: Sevelamer dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Since sevelamer is not absorbed by the body, an overdose of this medication is not likely to cause life-threatening symptoms.

What should I avoid while taking sevelamer?

Avoid taking any other medicines within 1 hour before or 3 hours after you take sevelamer. Sevelamer can bind to other medications and make them less effective.

Do not take calcium or other mineral supplements without your doctor's advice. Use only the specific type of calcium or mineral supplement your doctor recommends.

Sevelamer side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
  • severe stomach pain or constipation; or

  • fever, chills, body aches, flu symptoms.

Less serious side effects may include:

  • upset stomach;

  • stomach pain, gas;

  • nausea, vomiting;

  • diarrhea; or

  • constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Sevelamer Dosing Information

Usual Adult Dose for Hyperphosphatemia of Renal Failure:

Initial:Patients not taking a phosphate binder:800 mg to 1600 mg orally three times daily with each meal based on serum phosphorus level:Phosphorus greater than 5.5 and less than 7.5 mg/dL = 800 mgPhosphorus greater than or equal to 7.5 and less than 9.0 mg/dL = 1600 mgPhosphorus greater than or equal to 9.0 mg/dL = 1600 mgPatients switching from calcium acetate to sevelamer: For each calcium acetate 667 mg tablet used per meal, give sevelamer 800 mg per meal.Patients switching from sevelamer hydrochloride to carbonate:Dosage should be prescribed on a gram per gram basis.Maximum daily dose studied for sevelamer hydrochloride is 13,000 mg and for carbonate is 14,000 mg.

What other drugs will affect sevelamer?

The following drugs can interact with sevelamer. Tell your doctor if you are taking any of these:

  • ciprofloxacin (Cipro);

  • levothyroxine (Synthroid, Levothroid, Levoxyl);

  • a heart rhythm medication; or

  • a seizure medication.

This list is not complete and there may be other drugs that can interact with sevelamer. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about sevelamer.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 7.01. Revision Date: 12/14/2009 12:55:45 PM.
  • sevelamer Advanced Consumer (Micromedex) - Includes Dosage Information
  • Sevelamer Professional Patient Advice (Wolters Kluwer)
  • Sevelamer MedFacts Consumer Leaflet (Wolters Kluwer)
  • Renagel Prescribing Information (FDA)
  • Renagel Consumer Overview
  • Renvela Prescribing Information (FDA)
  • Renvela Consumer Overview