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Drugs reference index «Selegiline»


Brand names: Emsam

Why is Selegiline prescribed?

Emsam is a skin patch prescribed to treat major depression.

Most important fact about Selegiline

Antidepressants can increase the risk of suicidal thinking and behavior in children and teenagers. Adult and pediatric patients taking antidepressants should be watched closely for changes in moods or actions, especially when they first start therapy or when their dose is increased or decreased. Patients and their families should contact the doctor immediately if new symptoms develop or seem to get worse. Signs to watch for include anxiety, hostility, insomnia, restlessness, impulsive or dangerous behavior, and thoughts about suicide or dying.

How should you take Selegiline?

Apply an Emsam patch to dry, smooth skin on your upper chest or back (below the neck and above the waist), upper thigh or to the outer surface of the upper arm. Choose a new site each time you change your patch. Do not use the same site two days in a row. The patch delivers medicine for 24 hours.

  • If you miss a dose...If you forget to change your patch after 24 hours, remove the old patch, put on a new patch in a different area and continue to follow your original schedule.
  • Storage instructions...Store at room temperature, in their original pouches.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Selegiline.

  • Side effects may include:Decrease in blood pressure, increased depression, mania or hypomania

Why should Selegiline not be prescribed?

You should not use Emsam if you are taking another medication that will interact with it, or if you are allergic to any of the ingredients in it. Talk with your doctor to find the best way to treat depression.

Special warnings about Selegiline

You must not eat foods or drink beverages that contain high amounts of tyramine while using the Emsam 9 milligrams or 12 milligrams patches. You do not have to make any diet changes with the Emsam 6 milligrams patch. Do not take other medicines while using Emsam or for 2 weeks after you stop using it unless your doctor has told you it is okay. Do not drive or operate dangerous machinery until you know how Emsam affects you. Emsam may impair your judgment, ability to think, or coordination.

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Emsam. Also, talk to your doctor about your complete medical history, especially if you have heart problems, manic episodes, seizures, fainting, or are pregnant.

Possible food and drug interactions when taking Selegiline

If Emsam is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Emsam with the following:

Anxiety medicationDiet or weight-loss pillsOther antidepressants, especially monoamine oxidase inhibitors (MAOIs)Pain medicationSeizure medicationSt. John's wort

While on Emsam, it is best to avoid tyramine-rich foods such as dried or aged meats (e.g., sausages and salamis), fava beans, aged cheeses, tap beers, yeast, sauerkraut, and soybean products.

Special information if you are pregnant or breastfeeding

The effects of Emsam during pregnancy and breastfeeding are unknown. Talk with your doctor before taking Selegiline if you are pregnant, plan to become pregnant, or are breastfeeding.

Recommended dosage for Selegiline


Emsam comes in three patch strengths: 6 milligrams, 9 milligrams, and 12 milligrams. Each patch delivers medicine for 24 hours.


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

  • Selegiline Prescribing Information (FDA)
  • Selegiline MedFacts Consumer Leaflet (Wolters Kluwer)
  • selegiline Advanced Consumer (Micromedex) - Includes Dosage Information
  • Eldepryl Consumer Overview
  • Emsam System MedFacts Consumer Leaflet (Wolters Kluwer)
  • Emsam Advanced Consumer (Micromedex) - Includes Dosage Information
  • Emsam Consumer Overview
  • Emsam Prescribing Information (FDA)
  • Zelapar Orally Disintegrating Tablets MedFacts Consumer Leaflet (Wolters Kluwer)
  • Zelapar Consumer Overview

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