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Drugs reference index «Saxagliptin»


Generic Name: Saxagliptin (SAX-a-GLIP-tin)Brand Name: Onglyza

Saxagliptin is used for:

Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the amount of insulin released by your body, and by decreasing the amount of sugar made by your body.

Do NOT use Saxagliptin if:

  • you are allergic to any ingredient in Saxagliptin
  • you have type 1 diabetes
  • you have high blood ketone levels (diabetic ketoacidosis)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Saxagliptin :

Some medical conditions may interact with Saxagliptin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems or are on dialysis
  • if you have HIV, an unusual or prolonged infection, or a history of high blood ketone levels (diabetic ketoacidosis)
  • if you are using insulin

Some MEDICINES MAY INTERACT with Saxagliptin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Thiazolidinediones (eg, pioglitazone) because the risk of peripheral edema (swelling of the hands and feet) may be increased
  • Atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, or telithromycin because they may increase the risk of Saxagliptin 's side effects
  • Sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Saxagliptin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Saxagliptin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Saxagliptin :

Use Saxagliptin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Saxagliptin . Talk to your pharmacist if you have questions about this information.
  • Take Saxagliptin by mouth with or without food.
  • Check with your doctor before you eat grapefruit or drink grapefruit juice while you are using Saxagliptin .
  • Continue to take Saxagliptin even if you feel well. Do not miss any doses.
  • If you miss a dose of Saxagliptin , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Saxagliptin .

Important safety information:

  • Carry an ID card at all times that says you have diabetes.
  • Follow the diet and exercise program given to you by your health care provider. Proper diet, regular exercise, and regular blood sugar testing are important for best results with Saxagliptin .
  • Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Saxagliptin exactly as prescribed, tell your doctor.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • It may be harder to control your blood sugar during times of stress such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor.
  • The risk of low blood sugar may be increased when Saxagliptin is used along with certain other medicines for diabetes (eg, sulfonylureas). Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
  • Lab tests, including fasting blood glucose, glycosylated hemoglobin, and kidney function, may be performed while you use Saxagliptin . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Saxagliptin with caution in the ELDERLY; they may be more sensitive to its effects.
  • Saxagliptin should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Saxagliptin while you are pregnant. It is not known if Saxagliptin is found in breast milk. If you are or will be breast-feeding while you use Saxagliptin , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Saxagliptin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; runny or stuffy nose; sore throat; upper respiratory infection.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue); frequent or painful urination; swelling of the hands or feet.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Saxagliptin :

Store Saxagliptin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Saxagliptin out of the reach of children and away from pets.

General information:

  • If you have any questions about Saxagliptin , please talk with your doctor, pharmacist, or other health care provider.
  • Saxagliptin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Saxagliptin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Saxagliptin Professional Patient Advice (Wolters Kluwer)
  • saxagliptin Advanced Consumer (Micromedex) - Includes Dosage Information
  • Onglyza Prescribing Information (FDA)
  • Onglyza Consumer Overview

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