Generic Name: regadenoson (re ga DEN oh son)Brand Names: Lexiscan
Regadenoson is a stress agent that works by increasing blood flow in the arteries of the heart.
Regadenoson is given in preparation for a radiologic (x-ray) examination of blood flow through the heart to test for coronary artery disease.
Regadenoson may also be used for other purposes not listed in this medication guide.
Before you receive regadenoson, tell your doctor if you have asthma or COPD, a history of heart disease, or if you have had an illness causing vomiting or diarrhea.
Avoid drinking coffee or other beverages with caffeine for at least 12 hours before your stress test.Tell your caregivers if you have a serious side effect such as chest pain or heavy feeling, pain spreading to the arm or shoulder, sweating, general ill feeling, wheezing or trouble breathing, slow heart rate, weak pulse, slow breathing, or fainting.
If you have certain conditions, you may need a dose adjustment or special tests to safely receive this medication. Before you receive regadenoson, tell your doctor if you have:
asthma or COPD (chronic obstructive pulmonary disease);
a history of heart disease; or
if you have had a prolonged illness that caused vomiting or diarrhea;
Regadenoson is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.
After regadenoson is injected, you will be given other intravenous (IV) medications that allow blood vessels to be seen more clearly on the radiologic examination.Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely during your stress test.
Since regadenoson is given by a healthcare professional in preparation for medical testing, you are not likely to be on a dosing schedule.
Overdose symptoms may include severe dizziness, increased heart rate, and warmth or tingly feeling.
Avoid drinking coffee or other beverages with caffeine for at least 12 hours before your stress test.
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);
wheezing, trouble breathing; or
feeling like you might pass out.
Less serious side effects may include:
nausea, stomach discomfort, decreased sense of taste;
mild chest discomfort; or
warmth, redness, or tingly feeling under your skin.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Radionuclide Myocardial Perfusion Study:
Recommended dose: 5 mL (0.4 mg regadenoson) by intravenous injectionRegadenoson should be administered as a rapid (approximately 10 seconds) injection into a peripheral vein using a 22 gauge or larger catheter or needle.A 5 mL saline flush should be administered immediately after the regadenoson injection.The radionuclide myocardial perfusion imaging agent should be administered 10 to 20 seconds after the saline flush. The radionuclide may be injected directly into the same catheter as regadenoson.
Tell your doctor about all other medications you use, especially:
dipyridamole (Persantine); or
theophylline (Elixophyllin, Theo-24, Uniphyl).
This list is not complete and there may be other drugs that can interact with regadenoson. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.