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Drugs reference index «Recombinate»

Recombinate


Recombinate

Generic Name: antihemophilic factor (Intravenous route, Injection route)

an-tee-hee-moe-FIL-ik FAK-tor

Commonly used brand name(s):

In the U.S.

  • Advate
  • Helixate FS
  • Hemofil-M
  • Hyate:C
  • Koate DVI
  • Kogenate FS
  • Kogenate FS w/BIO-SET
  • Monarc-M
  • Monoclate-P
  • Recombinate
  • Refacto
  • Xyntha

Available Dosage Forms:

  • Powder for Solution

Therapeutic Class: Antihemophilic Agent

Uses For Recombinate

Antihemophilic factor (AHF) is a protein produced naturally in the body. It helps the blood form clots to stop bleeding.

Hemophilia A, also called classical hemophilia, is a condition in which the body does not make enough AHF. If you do not have enough AHF and you become injured, your blood will not form clots as it should, and you may bleed into and damage your muscles and joints. One type of AHF is used to treat another condition called von Willebrand disease, in which there is a risk of bleeding. AHF also may be used for other conditions as determined by your doctor.

The AHF that your doctor will give you is obtained naturally from human or pig blood or artificially by a man-made process.

AHF obtained from human blood has been treated. It is not likely to contain harmful viruses such as hepatitis B virus; hepatitis C virus (non-A, non-B hepatitis); or human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS). The man-made and pork AHF products do not contain these viruses.

AHF is available only with your doctor's prescription.

Before Using Recombinate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in children and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.

Geriatric

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of AHF. Make sure you tell your doctor if you have any other medical problems.

Proper Use of antihemophilic factor

This section provides information on the proper use of a number of products that contain antihemophilic factor. It may not be specific to Recombinate. Please read with care.

Some medicines given by injection may sometimes be given at home to patients who do not need to be in the hospital. If you are using this medicine at home, your health care professional will teach you how to prepare and inject the medicine. You will have a chance to practice preparing and injecting it. Be certain that you understand exactly how the medicine is to be prepared and injected.

To prepare this medicine:

  • Take the dry medicine and the liquid (diluent) out of the refrigerator or freezer and bring them to room temperature, as directed by your doctor.
  • Wipe rubber surface of bottles with alcohol swab and allow to dry.
  • When injecting the liquid (diluent) into the dry medicine, aim the stream of liquid (diluent) against the wall of the container of dry medicine to prevent foaming.
  • Swirl the container gently to dissolve the medicine. Do not shake the container.
  • Check the solution to make sure it is clear. Do not use medicine if you can see anything solid in the solution or if the solution is cloudy

Use this medicine right away. It should not be kept longer than 3 hours after it has been prepared, as directed on the package or by your doctor.

A plastic disposable syringe and filter needle must be used with this medicine. The medicine may stick to the inside of a glass syringe, and you may not receive a full dose.

Do not reuse syringes and needles. Put used syringes and needles in a puncture-resistant disposable container, or dispose of them as directed by your health care professional.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • Your body weight.
  • The amount of AHF your body is able to make.
  • How much, how often, and where in your body you are bleeding.
  • Whether or not your body has built up a defense (antibody) against this medicine.

Missed Dose

Call your doctor or pharmacist for instructions.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Some AHF products must be stored in the refrigerator and some in the freezer. However, some of them may be kept at room temperature for short periods of time. Store this medicine as directed by your doctor or by the manufacturer.

Precautions While Using Recombinate

If you were recently diagnosed with hemophilia A, you should receive hepatitis A and hepatitis B vaccines to reduce even further your risk of getting hepatitis A or B from antihemophilic factor.

It is recommended that you carry identification stating that you have hemophilia A, and what medicine you are using. If you have any questions about what kind of identification to carry, check with your health care professional.

After a while, your body may build up a defense (antibody) against this medicine. Tell your doctor if this medicine seems to be less effective than usual.

Recombinate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor may watch for others by doing certain tests.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare
  • Changes in facial skin color
  • fast or irregular breathing
  • puffiness or swelling of the eyelids or around the eyes
  • shortness of breath, troubled breathing, tightness in chest, and/or wheezing
  • skin rash, hives, and/or itching

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare
  • Chills
  • fever
  • nausea
  • tenderness, pain, swelling, warmth, skin discoloration, and noticeable veins over affected area
  • sensation of burning, warmth, heat, numbness, tightness, or tingling
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Burning, stinging, or swelling at place of injection
  • dizziness or lightheadedness
  • dry mouth or bad taste in mouth
  • headache
  • nosebleed
  • redness of face
  • vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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  • Recombinate Prescribing Information (FDA)
  • Antihemophilic Factor Professional Patient Advice (Wolters Kluwer)
  • Advate Consumer Overview
  • Advate MedFacts Consumer Leaflet (Wolters Kluwer)
  • Helixate FS Prescribing Information (FDA)
  • Kogenate Consumer Overview
  • Kogenate FS Prescribing Information (FDA)
  • Kogenate FS MedFacts Consumer Leaflet (Wolters Kluwer)
  • Monoclate-P Prescribing Information (FDA)
  • Xyntha MedFacts Consumer Leaflet (Wolters Kluwer)
  • Xyntha Consumer Overview