Rasburicase can cause a severe allergic reaction. If you develop new symptoms such as chest pain, trouble breathing, severe dizziness, a rash, or hives, stop using Rasburicase and seek immediate medical attention. Do not restart Rasburicase if a severe allergic reaction has occurred. Consult your doctor or pharmacist for more details.
Do not use Rasburicase if you have a metabolic condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency because it can severely damage your red blood cells, leading to anemia (hemolysis). If you are of African or Mediterranean descent, you may be at higher risk for G6PD deficiency and should be tested to see if you have this condition before starting Rasburicase .
Rasburicase can cause a condition that affects the ability of your red blood cells to carry oxygen (methemoglobinemia). Do not restart Rasburicase if this effect occurs. Consult your doctor for more details.
Rasburicase can interfere with accurate measurements of uric acid in the blood, resulting in falsely low levels. Be sure to tell all lab personnel that you are using Rasburicase .
Preventing high blood levels of uric acid from occurring in patients with certain types of cancer (eg, leukemia, lymphoma, solid malignant tumors) who are receiving cancer chemotherapy treatment.
Rasburicase is a urate-oxidase enzyme. When chemotherapy is given, cancer cells are destroyed, releasing large amounts of uric acid into the blood. Rasburicase works by allowing uric acid to be more easily removed from the body by the kidneys.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Rasburicase . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Rasburicase . However, no specific interactions with Rasburicase are known at this time.
Ask your health care provider if Rasburicase may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Rasburicase as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Rasburicase .
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; diarrhea; headache; mouth sores or ulcers; nausea; stomach pain; vomiting.Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue or gray skin color; chest pain; chills; coughing up blood; dark urine; fever; irregular heartbeat; numbness or tingling of the skin; persistent sore throat; severe dizziness; shortness of breath, trouble breathing, or wheezing; swelling of the hands or feet; weakness; yellowing of the eyes and skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.Proper storage of Rasburicase :
Rasburicase is usually handled and stored by a health care provider. If you are using Rasburicase at home, store Rasburicase as directed by your pharmacist or health care provider. Keep Rasburicase out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Rasburicase . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.