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Drugs reference index «ranibizumab Intraocular»

ranibizumab (Intraocular route)

ra-ni-BIZ-oo-mab

Commonly used brand name(s):

In the U.S.

  • Lucentis

Available Dosage Forms:

  • Solution

Therapeutic Class: Ophthalmologic Agent

Pharmacologic Class: Monoclonal Antibody

Uses For ranibizumab

Ranibizumab is used to treat neovascular (wet) age-related macular degeneration (AMD). AMD is a disorder of the retina of the eye that causes blurring of vision or blindness .

ranibizumab is available only with your doctor's prescription .

Before Using ranibizumab

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ranibizumab, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to ranibizumab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ranibizumab in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of ranibizumab in the elderly .

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of ranibizumab. Make sure you tell your doctor if you have any other medical problems, especially:

  • Eye infection—Ranibizumab should not be used in patients with an infection in or around the eye .
  • Glaucoma—ranibizumab may increase eye pressure after injection. Your doctor will monitor your eye pressure during the week after every injection .

Proper Use of ranibizumab

A doctor will give you ranibizumab. Ranibizumab is given through a shot into the eye .

ranibizumab is usually given once a month (about 28 days). In some patients, it may be given once every three months after the first four injections .

Precautions While Using ranibizumab

Your doctor will want to check your progress at regular visits, especially during the first few weeks that you receive ranibizumab .

Serious eye problems may occur after treatment with ranibizumab. Check with your doctor immediately if your eye becomes red, sensitive to light, painful or develops a change in vision several days after your treatment. Also, tell your doctor if you are having an increased pressure in the eye .

ranibizumab may increase your risk of blood clots. Check with your doctor right away if you are having pain in your chest, groin, or legs, especially the calves; difficulty breathing; severe, sudden headache; slurred speech; sudden, unexplained shortness of breath; sudden loss of coordination; sudden, severe weakness or numbness in your arm or leg; or vision changes .

ranibizumab Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
  • Abdominal pain
  • bladder pain
  • blindness
  • bloody eye
  • bloody or cloudy urine
  • blurred vision or loss of vision
  • body aches or pain
  • chest pain
  • chills
  • cough
  • cough producing mucus
  • decreased vision or other changes in vision
  • diarrhea
  • difficult, burning, or painful urination
  • difficulty breathing
  • disturbed color perception
  • dizziness
  • double vision
  • dry eye
  • ear congestion or pain
  • eye pain
  • fainting
  • fast, slow, or irregular heartbeat
  • feeling of having something in the eye
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • halos around lights
  • head congestion
  • headache
  • hoarseness, loss of voice, or other voice changes
  • joint pain
  • large amount of cholesterol in the blood
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nasal congestion
  • nausea or vomiting
  • nervousness
  • night blindness
  • overbright appearance of lights
  • pain or tenderness around eyes and cheekbones
  • pale skin
  • pounding in the ears
  • red, sore eyes
  • redness of the white part of eyes or inside of eyelids
  • redness, swelling, and/or itching of eyelid
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • sensitivity of eye to light
  • shivering
  • shortness of breath
  • sneezing
  • sore throat
  • stuffy or runny nose
  • sweating
  • tearing
  • tightness in chest
  • trouble sleeping
  • troubled breathing
  • tunnel vision
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • watering of eyes
  • wheezing
Less common
  • Dry mouth
  • fainting
  • fatigue
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • loss of consciousness
  • pain in chest, groin, or legs, especially the calves
  • painful blisters on trunk of body
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in arm or leg
  • sudden, unexplained shortness of breath
  • unexplained weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Back pain
  • difficulty having a bowel movement (stool)
  • difficulty moving
  • muscle stiffness
  • sleeplessness
  • swelling or redness in joints
  • unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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