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Drugs reference index «Propranolol HCl Intensol»

Propranolol HCl Intensol


Propranolol HCl Intensol

Generic Name: propranolol (Oral route)

proe-PRAN-oh-lol

Oral routeCapsule, Extended Release
  • Angina Pectoris:
    • There have been reports of exacerbation of angina and, in some cases, myocardial infarction, following abrupt discontinuance of propranolol therapy. Therefore, when discontinuance of propranolol is planned, the dosage should be gradually reduced over at least a few weeks, and the patient should be cautioned against interruption or cessation of therapy without a physician’s advice. If propranolol therapy is interrupted and exacerbation of angina occurs, it is usually advisable to reinstitute propranolol therapy and take other measures appropriate for the management of angina pectoris. Since coronary artery disease may be unrecognized, it may be prudent to follow the above advice in patients considered at risk of having occult atherosclerotic heart disease who are given propranolol for other indications .

Reports of exacerbation of angina and myocardial infarction have been noted following abrupt discontinuance of propranolol. When discontinuance of propranolol is planned, dosage should be gradually reduced over at least a few weeks, and the patient should be cautioned against interruption or cessation of therapy. If propranolol therapy is interrupted and exacerbation of angina occurs, reinstitution of propranolol and management of angina is advised. Since coronary artery disease may be unrecognized, it may be prudent to follow the above advice in patients considered at risk of having occult atherosclerotic heart disease who are given propranolol for other indications .

Commonly used brand name(s):

In the U.S.

  • Inderal
  • Inderal LA
  • InnoPran XL
  • Propranolol HCl Intensol

Available Dosage Forms:

  • Tablet
  • Capsule, Extended Release
  • Solution

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Beta-Adrenergic Blocker, Nonselective

Uses For Propranolol HCl Intensol

Propranolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Propranolol is also used to treat severe chest pain (angina), migraine headaches, or hypertrophic subaortic stenosis (thickened heart muscle) .

This medicine may also be used to treat irregular heartbeats, tremors, or pheochromocytoma (adrenal gland tumor). It may also be used to reduce the risk of death in patients who have heart attacks .

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart .

This medicine is available only with your doctor's prescription .

Before Using Propranolol HCl Intensol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of propranolol capsules and tablets in the pediatric population. Safety and efficacy have not been established .

Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of propranolol oral solution in children .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of propranolol in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment of dosage in patients receiving propranolol .

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Albuterol
  • Amiodarone
  • Arformoterol
  • Bambuterol
  • Bitolterol
  • Broxaterol
  • Bupivacaine
  • Clenbuterol
  • Clonidine
  • Colterol
  • Diatrizoate
  • Diltiazem
  • Dronedarone
  • Epinephrine
  • Fenoldopam
  • Fenoterol
  • Fentanyl
  • Formoterol
  • Haloperidol
  • Hexoprenaline
  • Isoetharine
  • Levalbuterol
  • Lidocaine
  • Mefloquine
  • Mepivacaine
  • Metaproterenol
  • Pirbuterol
  • Prilocaine
  • Procaterol
  • Reproterol
  • Rimiterol
  • Ritodrine
  • Salmeterol
  • Terbutaline
  • Tretoquinol
  • Tulobuterol
  • Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Acetohexamide
  • Alfuzosin
  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Amlodipine
  • Arbutamine
  • Benfluorex
  • Bunazosin
  • Calcium Carbonate
  • Chlorpromazine
  • Chlorpropamide
  • Cimetidine
  • Digoxin
  • Dihydroergotamine
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Disopyramide
  • Doxazosin
  • Ergotamine
  • Felodipine
  • Flecainide
  • Fluvoxamine
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Guar Gum
  • Guggul
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Lacidipine
  • Lercanidipine
  • Magaldrate
  • Manidipine
  • Metformin
  • Mibefradil
  • Miglitol
  • Moxisylyte
  • Nicardipine
  • Nifedipine
  • Nilvadipine
  • Nimodipine
  • Nisoldipine
  • Nitrendipine
  • Phenoxybenzamine
  • Phentolamine
  • Phenylephrine
  • Piperine
  • Pranidipine
  • Prazosin
  • Propoxyphene
  • Quinidine
  • Repaglinide
  • Rifapentine
  • Rizatriptan
  • Sertraline
  • St John's Wort
  • Tamsulosin
  • Terazosin
  • Tolazamide
  • Tolbutamide
  • Trimazosin
  • Troglitazone
  • Tubocurarine
  • Urapidil
  • Zileuton

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma or
  • Bradycardia (slow heartbeat) or
  • Heart block or
  • Heart failure or
  • Tremors due to Parkinson's disease—Should not use in patients with these conditions .
  • Diabetes or
  • Hyperthyroidism (overactive thyroid) or
  • Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat .
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal from the body .
  • Lung disease (e.g., bronchitis, emphysema)—May cause difficulty with breathing in patients with this condition .
  • Wolff-Parkinson-White syndrome (rare heart condition)—May cause very slow heartbeat in patients with this condition .

Proper Use of propranolol

This section provides information on the proper use of a number of products that contain propranolol. It may not be specific to Propranolol HCl Intensol. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet .

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .

Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous .

Swallow the long-acting oral capsules whole. Do not chew, crush, or open them .

Measure the concentrated oral solution, Intensol™ with the dropper that comes with the medicine. You may mix the concentrated solution with water, juice, soda, applesauce, or pudding to make it easier to swallow, then take the mixture right away .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For acute heart attack:
    • For oral dosage form (solution):
      • Adults—180 to 240 milligrams (mg) per day, given in divided doses.
      • Children—Dose is based on body weight and must be determined by your doctor .
    • For oral dosage form (tablets):
      • Adults—At first, 40 milligrams (mg) three times a day. Your doctor may increase your dose if needed.
      • Children—Use and dose must be determined by your doctor .
  • For adrenal gland tumor (pheochromocytoma):
    • For oral dosage form (solution):
      • Adults—60 milligrams (mg) per day, given in divided doses for three days before having surgery. In patients who cannot have surgery, the usual dose is 30 mg per day, given in divided doses.
      • Children—Dose is based on body weight and must be determined by your doctor .
    • For oral dosage form (tablets):
      • Adults—60 milligrams (mg) per day, given in divided doses for three days before having surgery. In patients who cannot have surgery, the usual dose is 30 mg per day, given in divided doses.
      • Children—Use and dose must be determined by your doctor .
  • For chest pain (angina):
    • For oral dosage form (long-acting oral capsules):
      • Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose if needed.
      • Children—Use and dose must be determined by your doctor .
    • For oral dosage form (solution):
      • Adults—80 to 320 milligrams (mg) per day, given in divided doses.
      • Children—Dose is based on body weight and must be determined by your doctor .
    • For oral dosage form (tablets):
      • Adults—80 to 320 milligrams (mg) per day, given in divided doses.
      • Children—Use and dose must be determined by your doctor .
  • For high blood pressure (hypertension):
    • For oral dosage form (long-acting oral capsules):
      • Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose if needed.
      • Children—Use and dose must be determined by your doctor .
    • For oral dosage form (solution):
      • Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
      • Children—Dose is based on body weight and must be determined by your doctor .
    • For oral dosage form (tablets):
      • Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
      • Children—Use and dose must be determined by your doctor .
  • For hypertrophic subaortic stenosis (thickened heart muscle):
    • For oral dosage form (long-acting oral capsules):
      • Adults—80 to 160 milligrams (mg) once a day.
      • Children—Use and dose must be determined by your doctor .
    • For oral dosage form (solution):
      • Adults—20 to 40 milligrams (mg) three or four times a day, given before meals and at bedtime.
      • Children—Dose is based on body weight and must be determined by your doctor .
    • For oral dosage form (tablets):
      • Adults—20 to 40 milligrams (mg) three or four times a day, given before meals and at bedtime.
      • Children—Use and dose must be determined by your doctor .
  • For irregular heartbeats:
    • For oral dosage form (solution):
      • Adults—10 to 30 milligrams (mg) three or four times a day, given before meals and at bedtime.
      • Children—Dose is based on body weight and must be determined by your doctor .
    • For oral dosage form (tablets):
      • Adults—10 to 30 milligrams (mg) three or four times a day, given before meals and at bedtime.
      • Children—Use and dose must be determined by your doctor .
  • For migraine headaches:
    • For oral dosage form (long-acting oral capsules):
      • Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose if needed.
      • Children—Use and dose must be determined by your doctor .
    • For oral dosage form (solution):
      • Adults—At first, 80 milligrams (mg) per day, given in divided doses. Your doctor may increase your dose if needed.
      • Children—Dose is based on body weight and must be determined by your doctor .
    • For oral dosage form (tablets):
      • Adults—At first, 80 milligrams (mg) per day, given in divided doses. Your doctor may increase your dose if needed.
      • Children—Use and dose must be determined by your doctor .
  • For tremors:
    • For oral dosage form (solution):
      • Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
      • Children—Dose is based on body weight and must be determined by your doctor .
    • For oral dosage form (tablets):
      • Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
      • Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Propranolol HCl Intensol

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects .

Propranolol may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort; dilated neck veins; extreme fatigue; irregular breathing; an irregular heartbeat; shortness of breath; swelling of the face, fingers, feet, or lower legs; weight gain; or wheezing .

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests .

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery .

This medicine may cause some people to become less alert than they are normally. If this side effect occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert while taking propranolol .

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, or loosening of the skin; chills; cough; diarrhea; fever; itching; joint or muscle pain; red skin lesions; sore throat; sores, ulcers, or white spots in your mouth or lips; or unusual tiredness or weakness .

Propranolol HCl Intensol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not determined
  • Abdominal pain and tenderness
  • black, tarry stools
  • blistering, peeling, or loosening of skin
  • blood in urine
  • bloody nose
  • bloody stools
  • blurred or loss of vision
  • body aches or pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • confusion about identity, place, and time
  • congestion
  • constipation
  • cough
  • cracks in the skin
  • crying
  • decreased awareness or responsiveness
  • decreased urine output
  • depersonalization
  • diarrhea
  • difficulty in breathing and/or swallowing
  • difficulty swallowing
  • dilated neck veins
  • disturbed color perception
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • double vision
  • dryness or soreness of throat
  • dysphoria
  • euphoria
  • extreme fatigue
  • fast, pounding, slow, or irregular heartbeat
  • fever and chills
  • general feeling of discomfort, illness, or weakness
  • hair loss
  • halos around lights
  • headaches
  • heavier menstrual periods
  • hives
  • hoarseness
  • irregular breathing
  • itching
  • lightheadedness, dizziness, or fainting
  • loss of heat from the body
  • mental depression
  • mimicry of speech or movements
  • muscle or joint pain
  • mutism
  • nausea
  • negativism
  • night blindness
  • noisy breathing
  • overbright appearance of lights
  • paleness or cold feeling in fingertips and toes
  • paranoia
  • peculiar postures or movements, mannerisms, or grimacing
  • pinpoint red or purple spots on skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • quick to react or overreact emotionally
  • rapidly changing moods
  • rectal bleeding
  • red irritated eyes
  • red skin lesions, often with a purple center
  • red, swollen skin
  • reddening of the skin, especially around the ears
  • runny nose
  • scaly skin
  • seeing, hearing, or feeling things that are not there
  • severe sleepiness
  • short-term memory loss
  • shortness of breath
  • skin irritation or rash, including rash that looks like psoriasis
  • skin rash
  • sores, ulcers, or white spots in mouth or on lips
  • sweating
  • swelling of eyes, face, fingers, feet, or lower legs
  • swollen glands
  • tender, swollen glands in neck
  • tightness in chest
  • tingling or pain in fingers or toes when exposed to cold
  • trouble in swallowing
  • troubled breathing
  • tunnel vision
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • voice changes
  • vomiting
  • weight gain
  • wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not determined
  • Dry eyes
  • heartburn
  • loss of strength or energy
  • muscle weakness
  • pain or discomfort in chest, upper stomach, or throat
  • sleeplessness
  • stomach cramps
  • trouble sleeping
  • unable to sleep
  • unusual drowsiness, dullness, or feeling of sluggishness
  • vivid dreams

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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