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Drugs reference index «prednisolone»

prednisolone


prednisolone

Generic Name: prednisolone (pred NIS oh lone)Brand names: Bubbli-Pred, Flo-Pred, Hydeltrasol, Key-Pred SP, Millipred, Orapred, Orapred ODT, Pediapred, Pred-Ject-50, Predacort 50, Predalone 50, Predate-50, Veripred 20, ...show all 25 brand names.Prelone, Hydeltra-T.B.A., Key-Pred, Cotolone, Depo-Predate (obsolete), Predicort-50, Predaject-50, Medicort, Predicort RP, Pri-Cortin 50, Predcor, Millipred DP

What is prednisolone?

Prednisolone is in a class of drugs called steroids. Prednisolone prevents the release of substances in the body that cause inflammation.

Prednisolone is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.

Prednisolone may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about prednisolone?

You should not use this medication if you are allergic to prednisolone, or if you have a fungal infection anywhere in your body.

Before taking prednisolone, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.

Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.

Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a "live" vaccine while you are taking prednisolone. Vaccines may not work as well while you are taking a steroid.

Do not stop using prednisolone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency.

What should I discuss with my healthcare provider before taking prednisolone?

You should not use this medication if you are allergic to prednisolone, or if you have a fungal infection anywhere in your body.

Steroid medication can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Before taking this medication, tell your doctor about any illness or infection you have had within the past several weeks.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • liver disease (such as cirrhosis);

  • kidney disease;

  • a thyroid disorder;

  • diabetes;

  • a history of malaria;

  • tuberculosis;

  • osteoporosis;

  • a muscle disorder such as myasthenia gravis;

  • glaucoma or cataracts;

  • herpes infection of the eyes;

  • stomach ulcers, ulcerative colitis, or diverticulitis;

  • depression or mental illness;

  • congestive heart failure; or

  • high blood pressure

FDA pregnancy category C. It is not known whether prednisolone is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Prednisolone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Steroids can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.

How should I take prednisolone?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Your steroid medication needs may change if you have unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.

Measure the liquid form of prednisolone with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Keep the disintegrating tablet (Orapred ODT) in its blister pack until you are ready to take the medicine. Open the package using dry hands, and peel back the foil from the tablet blister (do not push the tablet through the foil). Remove the tablet and place it in your mouth.

Allow the disintegrating tablet to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Steroids can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using prednisolone.

Do not stop using prednisolone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking steroid medication. Store prednisolone at room temperature away from moisture and heat.

See also: Prednisolone dosage in more detail

What happens if I miss a dose?

If you miss a dose or forget to take your medicine, contact your doctor or pharmacist for instructions.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

A single large dose of prednisolone is not expected to produce life-threatening symptoms. However, long-term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while taking prednisolone?

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a "live" vaccine while you are being treated with prednisolone. Vaccines may not work as well while you are taking a steroid.

Avoid drinking alcohol while you are taking prednisolone.

Prednisolone side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • problems with your vision;

  • swelling, rapid weight gain, feeling short of breath;

  • severe depression, unusual thoughts or behavior, seizure (convulsions);

  • bloody or tarry stools, coughing up blood;

  • pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate);

  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or

  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • sleep problems (insomnia), mood changes;

  • acne, dry skin, thinning skin, bruising or discoloration;

  • slow wound healing;

  • increased sweating;

  • headache, dizziness, spinning sensation;

  • nausea, stomach pain, bloating; or

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Prednisolone Dosing Information

Usual Adult Dose for Multiple Sclerosis:

Tablets and syrup for acute exacerbations: 200 mg daily for one week followed by 80 mg every other day for 1 month.

Usual Adult Dose for Anti-inflammatory:

Sodium phosphate:Oral: 5 to 60 mg per day in divided doses 1 to 4 times/day.Intravenous or Intramuscular: 4 to 60 mg/dayFor intra-articular, intralesional or soft tissue administration:Large joints: 10 to 20 mg Small joints: 4 to 5 mgBursae: 10 to 15 mgTendon sheaths: 2 to 5 mgSoft tissue infiltration: 10 to 30 mgGanglia: 5 to 10 mgInjectable suspension (tebutate) for intra-articular, intralesional or soft tissue administration:Large joints: 20 to 30 mg (doses > 40 mg not recommended)Small joints: 8 to 10 mgBursae: 20 to 30 mgTendon sheaths: 4 to 10 mgGanglia: 10 to 20 mgInjectable suspension (acetate) for intra-articular, intralesional or soft tissue administration: 4 to 100 mgBursae: 10 to 15 mgTendon sheaths: 2 to 5 mgSoft tissue infiltration: 10 to 30 mg

Usual Pediatric Dose for Immunosuppression:

Oral: 0.1 to 2 mg/kg/day in divided doses 1 to 4 times a day.Intravenous: 0.1 to 2 mg/kg/day in divided doses 1 to 4 times a day.

Usual Pediatric Dose for Asthma -- Acute:

Oral: 1 to 2 mg/kg/day in divided doses 1 to 2 times a day for 3 to 5 days.Intravenous: 2 to 4 mg/kg/day divided 3 or 4 times a day.

Usual Pediatric Dose for Nephrotic Syndrome:

First 3 episodes: Initial dose: 2 mg/kg/day (maximum dose 80 mg/day) until urine is free of protein for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose every other day for 4 weeks.Frequent relapses or long-term maintenance dose: 0.5 to 1 mg/kg/dose given every other day for 3 to 6 months.

What other drugs will affect prednisolone?

There are many other medicines that can interact with steroids. Below is only a partial list of these medicines:

  • aspirin (taken on a daily basis or at high doses);

  • a diuretic (water pill);

  • a blood thinner such as warfarin (Coumadin);

  • cyclosporine (Gengraf, Neoral, Sandimmune);

  • insulin or diabetes medications you take by mouth;

  • ketoconazole (Nizoral);

  • rifampin (Rifadin, Rifater, Rifamate, Rimactane); or

  • seizure medications such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

This list is not complete and there may be other drugs that can interact with prednisolone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about prednisolone.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 5.03. Revision Date: 06/25/2009 3:19:15 PM.
  • Flo-Pred Prescribing Information (FDA)
  • Flo-Pred Consumer Overview
  • Millipred DP MedFacts Consumer Leaflet (Wolters Kluwer)
  • Orapred Solution MedFacts Consumer Leaflet (Wolters Kluwer)
  • Orapred Consumer Overview
  • Orapred ODT Detailed Consumer Information (PDR)
  • Orapred ODT MedFacts Consumer Leaflet (Wolters Kluwer)
  • PediaPred Liquid MedFacts Consumer Leaflet (Wolters Kluwer)
  • Pediapred Detailed Consumer Information (PDR)
  • Prednisolone tablets Prescribing Information (FDA)
  • Prednisolone MedFacts Consumer Leaflet (Wolters Kluwer)
  • Prednisolone Professional Patient Advice (Wolters Kluwer)
  • Prelone Syrup MedFacts Consumer Leaflet (Wolters Kluwer)

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