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Drugs reference index «ondansetron injection»

ondansetron injection
ondansetron injection
ondansetron injection


ondansetron

Generic Name: ondansetron (injection) (on DAN se tron)Brand Names: Zofran

What is ondansetron injection?

Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Ondansetron injection is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy).

Ondansetron injection may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about ondansetron injection?

Before receiving ondansetron injection, tell your doctor if you have liver disease, a personal or family history of Long QT syndrome, or if you have had an allergic reaction to any medicine similar to ondansetron, including dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).

Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by ondansetron injection.

Ondansetron injection can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Call your doctor at once if you have stiffness in your neck, or muscle spasms or twitching (especially in your face).

There may be other drugs that can affect ondansetron injection. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I discuss with my health care provider before using ondansetron injection?

Before using ondansetron injection, tell your doctor if you have:

  • liver disease;
  • a history of allergic reaction to any medicine similar to ondansetron, including dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi); or

  • a personal or family history of Long QT syndrome.

If you have any of these conditions, you may not be able to use ondansetron injection, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Ondansetron can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is ondansetron injection used?

Ondansetron injection is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. In most cases, only one dose of ondansetron injection is given just before the start of surgery or chemotherapy. Sometimes a second and third dose are also given at 4 hours and 8 hours after the first dose. The medicine must be given through an IV infusion, and can take up to 15 minutes to complete.

Ondansetron injection is not for preventing nausea or vomiting that are caused by factors other than chemotherapy or surgery.

If you receive this medicine at home and you keep your medicine there, store ondansetron injection at room temperature away from heat and light.

What happens if I miss a dose?

Call your doctor for instructions.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

Symptoms of an ondansetron overdose may include sudden loss of vision, severe constipation, feeling light-headed, fainting.

What should I avoid while receiving ondansetron injection?

Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by ondansetron injection.

Ondansetron injection can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Ondansetron injection side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • blurred vision or temporary blindness;

  • muscle spasm or twitching, especially in your face; or

  • stiffness in your neck.

Other less serious side effects are more likely to occur, such as:

  • diarrhea;

  • headache;

  • fever;

  • drowsiness;

  • blurred vision; or

  • pain or redness where the medicine is injected.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Ondansetron Dosing Information

Usual Adult Dose for Nausea/Vomiting -- Chemotherapy Induced:

Initial: 0.15 mg/kg IV given 30 minutes before the start of emetogenic therapy, then repeat the dose at 4 hour intervals for 2 additional doses. A continuous IV dose option consists of 8 mg followed by 1 mg/hr for the next 24 hours.Alternative therapies:With highly emetogenic chemotherapy, give a onetime IV dose of 32 mg, 30 minutes before the start of single-day therapy; Infuse over 15 minutes. Alternatively, give a single 24 mg orally 30 minutes before therapy.With moderate emetogenic chemotherapy, give 8 mg orally 30 minutes before the start of therapy, then 8 mg given 8 hours after the first dose. Thereafter, give 8 mg every 12 hours for 1 to 2 days after emetogenic therapy is complete.

Usual Adult Dose for Nausea/Vomiting:

Initial: 0.15 mg/kg IV given 30 minutes before the start of emetogenic therapy, then repeat the dose at 4 hour intervals for 2 additional doses. A continuous IV dose option consists of 8 mg followed by 1 mg/hr for the next 24 hours.Alternative therapies:With highly emetogenic chemotherapy, give a onetime IV dose of 32 mg, 30 minutes before the start of single-day therapy; Infuse over 15 minutes. Alternatively, give a single 24 mg orally 30 minutes before therapy.With moderate emetogenic chemotherapy, give 8 mg orally 30 minutes before the start of therapy, then 8 mg given 8 hours after the first dose. Thereafter, give 8 mg every 12 hours for 1 to 2 days after emetogenic therapy is complete.

Usual Adult Dose for Nausea/Vomiting -- Postoperative:

4 mg IV (undiluted) over 2 to 5 minutes, or IM, immediately before induction of anesthesia or postoperatively if nausea or vomiting occurs immediately after surgery. Alternatively, 16 mg orally 1 hour before induction of anesthesia

Usual Adult Dose for Nausea/Vomiting--Radiation Induced:

8 mg orally every 8 hours, give the first dose 1 to 2 hours prior to radiotherapy.

Usual Adult Dose for Pruritus:

Study (n=150) - Induced by Intrathecal Fentanyl8 mg IV before spinal anesthesia.

Usual Adult Dose for Alcohol Dependence:

Study (n=321) - Early onset alcoholism4 mcg/kg two times daily.

Usual Adult Dose for Postanesthetic Shivering:

Study (n=82)8 mg IV, 3 to 5 minutes before the induction of anesthesia.

Usual Pediatric Dose for Nausea/Vomiting -- Postoperative:

Child 1 month to 12 years:40 kg or less: 0.1 mg/kg single dose IV, administered over 2 to 5 minutes, immediately prior to or following anesthesia induction, or postoperatively if nausea and/or vomiting present shortly after surgery.40 kg or more: 4 mg single dose IV, administered over 2 to 5 minutes, immediately prior to or following anesthesia induction, or postoperatively if nausea and/or vomiting present shortly after surgery.

Usual Pediatric Dose for Nausea/Vomiting -- Chemotherapy Induced:

Child 6 months to 18 years: 0.15 mg/kg as an IV infusion (over 15 minutes) administered 30 minutes before the start of emetogenic therapy, then at 4 and 8 hours after the first dose, respectively.4 to 11 years: 4 mg orally given 30 minutes before the start of emetogenic therapy, then 4 mg orally 4 and 8 hours after the first dose. Thereafter, 4 mg orally every 8 hours for 1 to 2 days after emetogenic therapy is complete.11 years or older:: 8 mg orally 3 times daily, or 24 mg orally once daily.

Usual Pediatric Dose for Gastroenteritis:

Study (n=145) - Control of emesis during the ED phase of oral rehydration:6 months to 12 months: 1.6 mg orally every 8 hours1 year to 3 years: 3.2 mg orally every 8 hours4 years or older: 4 mg orally every 8 hoursDosage was administered 15 minutes before the start of oral rehydration.

What other drugs will affect ondansetron injection?

Before receiving ondansetron injection, tell your doctor if you are using any of the following drugs:

  • phenytoin (Dilantin), phenobarbital (Luminal);

  • carbamazepine (Carbatrol, Tegretol);

  • tramadol (Ultram);

  • rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, Rifater);

  • amiodarone (Cordarone), mibefradil (Posicor);

  • cimetidine (Tagamet);

  • clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Ery-Tab); or

  • HIV medicines such as indinavir (Crixivan), saquinavir (Invirase), ritonavir (Norvir), or nelfinavir (Viracept).

If you are using any of these drugs, you may not be able to use ondansetron injection, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect ondansetron injection. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist has more information about ondansetron injection written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.04. Revision Date: 4/12/2009 4:38:32 PM.
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