Generic Name: nilutamide (nih LUTE ah mide)Brand Names: Nilandron
Nilutamide is an antiandrogen. It works in the body to prevent the actions of androgens (male hormones).
Nilutamide is used in the treatment of prostate cancer.
Nilutamide may also be used for purposes other than those listed in this medication guide.
Nilutamide may cause a delay in your ability to see in the dark after being in a lighted area. Use caution when driving at night, when entering into a tunnel, and in other similar situations. Tinted glasses may alleviate this side effect.
Before taking this medication, tell your doctor if you have
liver disease or
asthma or another lung disease.
You may not be able to take nilutamide, or you may require a lower dose or special monitoring if you have any of the conditions listed above.Nilutamide is in the FDA pregnancy category C. This means that it is not known whether nilutamide will harm an unborn baby. Nilutamide is not indicated for use by women. Do not take this medication if you are pregnant or are planning a pregnancy. It is not known whether nilutamide passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.
Take nilutamide exactly as directed by your doctor. However, if you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.Take each dose with a full glass of water.
Nilutamide can be taken with or without food or milk.
Treatment with nilutamide should be started on the day of or on the day after surgical castration to have maximum benefits.
Try to take your dose of nilutamide at the same time every day.Do not stop taking this medication without first talking to your doctor. Store nilutamide at room temperature away from moisture and heat.
See also: Nilutamide dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.
Symptoms of a nilutamide overdose are not known but might include decreased activity, slow breathing, dizziness, watering eyes, decreased appetite, vomiting, and sedation.
Nilutamide may cause a delay in your ability to see in the dark after you have been in a lighted area. Use caution when driving at night, when entering a tunnel, and in similar situations. Tinted glasses may alleviate this side effect.
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives),
shortness of breath, cough, chest pain, or fever;
liver damage (yellow skin or eyes, dark urine, itching, persistent appetite loss, pain in the upper right stomach area, or unexplained flulike symptoms).
Other less serious side effects may be more likely to occur. Continue to take nilutamide and talk to your doctor if you experience
nausea or vomiting,
loss of appetite,
poor visual adaptation to darkness or other changes in vision.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Prostate Cancer:
For use in combination with surgical castration for the treatment of metastatic prostate cancer (Stage D 2 ):Recommended dosage: 300 mg once a day for 30 days, followed thereafter by 150 mg once a day.
Before taking this medication, tell your doctor if you are taking any of the following medicines
phenytoin (Dilantin), or
theophylline (Theo-Dur, Theochron, Theolair, others).
You may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with nilutamide. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.