Melphalan should only be used under the supervision of a doctor experienced with the use of cancer medicines. Melphalan may cause a decrease in the body's blood cells (bone marrow suppression), which could cause bleeding problems or infection. It may also cause blood cell cancer (eg, leukemia). Notify your doctor immediately if you develop easy bleeding or bruising, unusual fatigue, or signs of an infection, such as persistent sore throat or fever.
Treating certain types of cancer.
Melphalan are an alkylating agent. It works by destroying resting and rapidly dividing tumor cells in certain types of cancer.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Melphalan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Melphalan. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Melphalan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Melphalan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Melphalan.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Hair loss; loss of appetite; nausea; vomiting.Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in urine or stools; chest pain; dark urine; diarrhea; fainting; fatigue; fever or chills; irregular or absent menstrual periods; joint pain; lower back or side pain; numbness of an arm or leg; persistent cough; persistent nausea or vomiting; shortness of breath; sore throat; sores on the mouth or lips; stomach pain; sudden severe dizziness, headache, or vomiting; swelling of hands, ankles, or feet; unusual bruising or bleeding; unusual lumps or growths; unusual tiredness or weakness; yellowing eyes and skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include diarrhea; intestinal bleeding; nausea; vomiting.Proper storage of Melphalan:
Store Melphalan in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Melphalan out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Melphalan. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.