Trade Names:Magnesium chloride- Injection, solution, concentrate 20% (1.97 mEq/mL)
Magnesium is an important activator of many enzyme systems, and deficits are accompanied by a variety of functional disturbances.
Approximately 25% to 30% protein bound.
Mainly in the urine.
Electrolyte replenisher in magnesium deficiencies.
Renal impairment; marked myocardial disease; comatose patients.
IV 4 g in 250 mL of dextrose 5% injection, at a rate not exceeding 3 mL/min (range, 1 to 40 g of magnesium chloride diluted appropriately).
Store at 59° to 86°F.
Administer magnesium with extreme caution because serious changes in cardiac conduction, which can result in heart block, may occur if administration of calcium is required to treat magnesium toxicity.CNS depressants (eg, barbiturates, narcotics)
Possible additive CNS depressant effects.Neuromuscular blocking agents
Potentiation of neuromuscular blockade.
None well documented.
Sharply lowered BP.
Flushing, hypothermia, sweating.
Monitor serum magnesium levels to guide need for continued dosage. Normal serum concentration is 1.5 to 2.5 mEq/L. Respiration and BP should be carefully observed during and after administration of magnesium chloride.
Category C .
Excreted in breast milk.
Use with caution; renal function impairment may lead to magnesium intoxication.
Some products contain aluminum. Aluminum may reach toxic levels with parenteral administration if kidney function is impaired. Premature neonates are particularly at risk.
Administer with caution if either occurs.
A preparation of a calcium salt should be readily available for IV injection to counteract potential serious signs of magnesium intoxication. As long as deep tendon reflexes are active, it is probable that the patient will not develop respiratory paralysis.
Decreased deep tendon reflexes, disappearance of patellar reflex, hypotension, muscle weakness, prolonged PR interval, prolonged QRS complex, prolonged QT interval, respiratory paralysis, sedation, sharp drop in BP.
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