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Drugs reference index «Foscavir»

Foscavir
Foscavir
Foscavir


Foscavir

Generic Name: foscarnet (Intravenous route)

fos-KAR-net

Intravenous routeSolution

Renal impairment is the major toxicity of foscarnet sodium. Frequent monitoring of serum creatinine, with dose adjustment for changes in renal function, and adequate hydration with administration of foscarnet sodium, is imperative.

Seizures, related to alterations in plasma minerals and electrolytes, have been associated with foscarnet sodium treatment. Therefore, patients must be carefully monitored for such changes and their potential sequelae. Mineral and electrolyte supplementation may be required.

Foscarnet sodium is indicated for use only in immunocompromised patients with CMV retinitis and mucocutaneous acyclovir-resistant HSV infections .

Renal impairment is the major toxicity of foscarnet sodium. Frequent monitoring of serum creatinine, with dose adjustment for changes in renal function, and adequate hydration with administration of foscarnet sodium, is imperative. Seizures, related to alterations in plasma minerals and electrolytes, have been reported. Mineral and electrolyte supplementation may be required .

Commonly used brand name(s):

In the U.S.

  • Foscavir

Available Dosage Forms:

  • Solution

Therapeutic Class: Antiviral

Pharmacologic Class: Viral DNA Polymerase Inhibitor

Uses For Foscavir

Foscarnet is used to treat the symptoms of cytomegalovirus (CMV) infection of the eyes in patients with acquired immune deficiency syndrome (AIDS). Foscarnet will not cure this eye infection, but it may help to control worsening of the symptoms. It is also used to treat herpes simplex virus (HSV) infections of the skin and mucous membranes in people who are immunocompromised and whose infections did not improve with other therapy. Foscarnet may also be used for other serious viral infections as determined by your doctor. However, it does not work in treating certain viruses, such as the common cold or the flu.

Foscarnet is administered only by or under the supervision of your doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, foscarnet is used in certain patients with the following medical conditions:

  • Cytomegalovirus infections in places other than the eyes, such as the lungs, esophagus, or intestines
  • Varicella-zoster infection (shingles) that does not respond to treatment with acyclovir in patients with HIV infection

Before Using Foscavir

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There is no specific information comparing use of foscarnet in children with use in other age groups. Foscarnet can cause serious side effects in any patient. Therefore, it is especially important that you discuss with the child's doctor the good that this medicine may do as well as the risks of using it.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of foscarnet in the elderly with use in other age groups.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Arsenic Trioxide
  • Bepridil
  • Cisapride
  • Levomethadyl
  • Mesoridazine
  • Pimozide
  • Probucol
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Ajmaline
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • Aprindine
  • Astemizole
  • Azimilide
  • Bretylium
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Cidofovir
  • Clarithromycin
  • Desipramine
  • Dibenzepin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Doxepin
  • Droperidol
  • Encainide
  • Enflurane
  • Erythromycin
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Gemifloxacin
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hydroquinidine
  • Ibutilide
  • Imipramine
  • Isoflurane
  • Isradipine
  • Lidoflazine
  • Lorcainide
  • Mefloquine
  • Nortriptyline
  • Octreotide
  • Pentamidine
  • Pirmenol
  • Prajmaline
  • Procainamide
  • Prochlorperazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Risperidone
  • Sematilide
  • Sertindole
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sultopride
  • Tedisamil
  • Telithromycin
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Vasopressin
  • Zolmitriptan
  • Zotepine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia—Foscarnet may cause or worsen anemia
  • Dehydration or
  • Kidney disease—Patients who are dehydrated or have kidney disease may have an increased chance of side effects

Proper Use of Foscavir

To ensure the best response, foscarnet must be given for the full time of treatment. Also, this medicine works best when there is a constant amount in the blood. To help keep the amount constant, foscarnet must be given on a regular schedule.

Several glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects foscarnet has on the kidneys.

This medicine may cause sores on the genitals (sex organs). Washing your genitals after urination may decrease the chance of your developing this problem.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For cytomegalovirus (CMV) retinitis induction (first stage of dosing):
      • Adults and children—The usual dose is 60 milligrams (mg) per kilogram (kg) (27.3 mg per pound) of body weight every eight hours for fourteen to twenty-one days. Each dose is injected slowly into a vein by an infusion pump over at least one hour.
    • For CMV retinitis maintenance (second stage of dosing):
      • Adults and children—The usual dose is 90 to 120 mg per kg (41 to 54.5 mg per pound) of body weight once a day. This dose is injected slowly into a vein by an infusion pump over at least two hours.
    • For herpes simplex infections:
      • Adults and children—The usual dose is 40 mg per kg (18.2 mg per pound) of body weight given either every eight or every twelve hours. This dose is injected slowly into a vein by an infusion pump over at least one hour. Treatment is usually continued for two to three weeks or until the infection in healed.

Precautions While Using Foscavir

It is very important that your doctor check your progress at regular visits. This will allow your doctor to check for possible unwanted effects.

It is also very important that your ophthalmologist (eye doctor) check your eyes at regular visits since you may have some loss of eyesight due to retinitis even while you are receiving foscarnet.

Foscavir Side Effects

Along with their needed effects, medicines like foscarnet can sometimes cause serious side effects such as kidney problems; these are described below. Foscarnet may also decrease the amount of calcium in your blood, causing you to have a tingling sensation around your mouth, and pain or numbness in your hands and feet. If this occurs, especially while you are receiving the medicine, notify your health care professional immediately.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Increased or decreased frequency of urination or amount of urine
  • increased thirst
Less common
  • Convulsions (seizures)
  • fever, chills, and sore throat
  • muscle twitching
  • pain at place of injection
  • pain or numbness in hands or feet
  • tingling sensation around mouth
  • tremor
  • unusual tiredness and weakness
Rare
  • Sores or ulcers on the mouth or throat, penis, or vulva

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach pain
  • anxious feeling
  • confusion
  • dizziness
  • headache
  • loss of appetite
  • nausea and vomiting
  • unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Foscavir Prescribing Information (FDA)
  • Foscavir Concise Consumer Information (Cerner Multum)
  • Foscavir MedFacts Consumer Leaflet (Wolters Kluwer)
  • Foscarnet Prescribing Information (FDA)

See Also...